Voltage-dependent calcium channel subunit alpha-2/delta-1
Also known as: CACNA2D1, CACNL2A, CCHL2A, MHS3
Function
The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Plays an important role in excitation-contraction coupling (By similarity).
Classification
- Family (Pfam)
- PF08473 VGCC_alpha2, PF00092 VWA, PF08399 VWA_N
- InterPro
- Ca_channel_alpha-2/delta, VDCC_a2/dsu, VWA_N, VWF_A, vWFA_dom_sf
- Functional cluster
- Mixed Regulatory & Membrane Proteins
Experimental structures · PDB · 30
- 7MIX EM 3.00A
- 7MIY EM 3.10A
- 7UHF EM 3.10A
- 7UHG EM 3.00A
- 7VFS EM 2.80A
- 7VFU EM 3.00A
- 7VFV EM 3.00A
- 7VFW EM 3.30A
- 7XLQ EM 3.10A
- 7YG5 EM 3.00A
- 8E59 EM 3.10A
- 8E5A EM 3.30A
- … and 18 more
A predicted model is available from AlphaFold.
Gene Ontology · 23
- GO:0070062 extracellular exosome
- GO:0098982 GABA-ergic synapse
- GO:1990454 L-type voltage-gated calcium channel complex
- GO:0098992 neuronal dense core vesicle
- GO:0005886 plasma membrane
- GO:0048787 presynaptic active zone membrane
- GO:0016529 sarcoplasmic reticulum
- GO:0005891 voltage-gated calcium channel complex
- GO:0046872 metal ion binding
- GO:0005245 voltage-gated calcium channel activity
- GO:0098703 calcium ion import across plasma membrane
- GO:0061577 calcium ion transmembrane transport via high voltage-gated calcium channel
- GO:0006816 calcium ion transport
- GO:0060402 calcium ion transport into cytosol
- GO:0086002 cardiac muscle cell action potential involved in contraction
- GO:1904646 cellular response to amyloid-beta
- GO:0086048 membrane depolarization during bundle of His cell action potential
- GO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus
- GO:1902514 regulation of calcium ion transmembrane transport via high voltage-gated calcium channel
- GO:0051924 regulation of calcium ion transport
- GO:0086091 regulation of heart rate by cardiac conduction
- GO:0098903 regulation of membrane repolarization during action potential
- GO:0060307 regulation of ventricular cardiac muscle cell membrane repolarization
Disease associations
- developmental and epileptic encephalopathy 110 MONDO:0859327
Drugs targeting this protein · 10
- PREGABALIN modulator
- BEPRIDIL HYDROCHLORIDE blocker
- GABAPENTIN ENACARBIL modulator
- IMAGABALIN modulator
- MIROGABALIN BESYLATE modulator
- SULOCTIDIL blocker
- PHLOROGLUCINOL blocker
- TERODILINE HYDROCHLORIDE blocker
- ATAGABALIN modulator
- GABAPENTIN modulator
Related proteins · sequence + function similarity
- Voltage-dependent calcium channel subunit alpha-2/delta-1 1.00
- Voltage-dependent calcium channel subunit alpha-2/delta-1 1.00
- Voltage-dependent calcium channel subunit alpha-2/delta-1 0.99
- Voltage-dependent calcium channel subunit alpha-2/delta-2 0.92
- Voltage-dependent calcium channel subunit alpha-2/delta-2 0.92
- Voltage-dependent calcium channel subunit alpha-2/delta-2 0.91
- VWFA and cache domain-containing protein 1 0.72
- VWFA and cache domain-containing protein 1 0.71
- Voltage-dependent calcium channel unc-36 0.71
- Voltage-dependent calcium channel unc-36 0.70
- Voltage-dependent calcium channel subunit alpha-2/delta-3 0.70
- Voltage-dependent calcium channel subunit alpha-2/delta-3 0.69
Co-cited proteins · studied together in the literature
- Voltage-dependent L-type calcium channel subunit beta-1 2 shared papers
- Voltage-dependent N-type calcium channel subunit alpha-1B 1 shared papers
- Voltage-dependent L-type calcium channel subunit beta-3 2 shared papers
- Voltage-dependent L-type calcium channel subunit alpha-1D 1 shared papers
- Calciseptine 1 shared papers
- Omega-conotoxin MVIIA 1 shared papers
- Voltage-dependent L-type calcium channel subunit alpha-1C 1 shared papers
Literature · 9 cited papers
- Structural basis for human Cav1.2 inhibition by multiple drugs and the neurotoxin calciseptine. Cell · 2023
- Biallelic CACNA2D1 loss-of-function variants cause early-onset developmental epileptic encephalopathy. Brain · 2022
- Structure of human Cav2.2 channel blocked by the painkiller ziconotide. Nature · 2021
- Identification of a disulfide bridge essential for structure and function of the voltage-gated Ca(2+) channel alpha(2)delta-1 auxiliary subunit. Cell Calcium · 2012
- Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. J. Proteome Res. · 2009
- Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. J. Proteome Res. · 2005
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
- Human neuronal voltage-dependent calcium channels: studies on subunit structure and role in channel assembly. Neuropharmacology · 1993
- Structure and functional expression of alpha 1, alpha 2, and beta subunits of a novel human neuronal calcium channel subtype. Neuron · 1992
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