Voltage-dependent N-type calcium channel subunit alpha-1B

UniProt Q00975 Organism Homo sapiens Gene CACH5, CACNA1B, CACNL1A5

Also known as: CACH5, CACNA1B, CACNL1A5

Function

Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This alpha-1B subunit gives rise to N-type calcium currents. N-type calcium channels belong to the 'high-voltage activated' (HVA) group. They are involved in pain signaling. Calcium channels containing alpha-1B subunit may play a role in directed migration of immature neurons. Mediates Ca(2+) release probability at hippocampal neuronal soma and synaptic terminals (By similarity).

Classification

Family (Pfam): PF08763 Ca_chan_IQ, PF16905 GPHH, PF00520 Ion_trans
InterPro: EF_hand_dom, GPHH_dom, Ion_trans_dom, VDCC_a1su_IQ, VDCC_alpha-1_subunit, VDCC_N_a1su, VDCCAlpha1, Volt_channel_dom_sf
Functional cluster: Membrane Transporters & GPCRs

Experimental structures · PDB · 7

2LCM NMR
7MIX EM 3.00A
7MIY EM 3.10A
7VFS EM 2.80A
7VFU EM 3.00A
7VFV EM 3.00A
7VFW EM 3.30A

A predicted model is available from AlphaFold.

Gene Ontology · 14

Disease associations

neurodevelopmental disorder with seizures and nonepileptic hyperkinetic movements MONDO:0032784

Drugs targeting this protein · 15

PREGABALIN modulator
BEPRIDIL HYDROCHLORIDE blocker
LEVETIRACETAM blocker
GABAPENTIN ENACARBIL modulator
IMAGABALIN modulator
RALFINAMIDE blocker
ELPETRIGINE blocker
SULOCTIDIL blocker
ZICONOTIDE blocker
PHLOROGLUCINOL blocker
CNV2197944 blocker
TERODILINE HYDROCHLORIDE blocker
ATAGABALIN modulator
Z160 blocker
GABAPENTIN modulator

Related proteins · sequence + function similarity

Co-cited proteins · studied together in the literature

Voltage-dependent calcium channel subunit alpha-2/delta-1 1 shared papers
Voltage-dependent L-type calcium channel subunit beta-3 1 shared papers
Omega-conotoxin MVIIA 1 shared papers

Literature · 7 cited papers

Structure of human Cav2.2 channel blocked by the painkiller ziconotide. Nature · 2021
Bi-allelic loss-of-function CACNA1B mutations in progressive epilepsy-dyskinesia. Am. J. Hum. Genet. · 2019
The CACNA1B R1389H variant is not associated with myoclonus-dystonia in a large European multicentric cohort. Hum. Mol. Genet. · 2015
CACNA1B mutation is linked to unique myoclonus-dystonia syndrome. Hum. Mol. Genet. · 2015
DNA sequence and analysis of human chromosome 9. Nature · 2004
Isolation and characterization of the 5'-upstream region of the human N-type calcium channel alpha1B subunit gene. Chromosomal localization and promoter analysis. J. Biol. Chem. · 1997
Structure and functional expression of an omega-conotoxin-sensitive human N-type calcium channel. Science · 1992

A document in the lmmol reference corpus — open public data (UniProt, GO, PDB, the literature graph) rendered as a single cross-linked page. Hover any link to preview its target.