Voltage-dependent calcium channel subunit alpha-2/delta-4

UniProt Q7Z3S7 Organism Homo sapiens Gene CACNA2D4

Also known as: CACNA2D4

Function

The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel.

Classification

Family (Pfam): PF08473 VGCC_alpha2, PF13768 VWA_3, PF08399 VWA_N
InterPro: Ca_channel_alpha-2/delta, VDCC_a2/dsu, VWA_N, VWF_A, vWFA_dom_sf
Functional cluster: Immunoglobulin-Domain Cell Adhesion Proteins

Gene Ontology · 5

Disease associations

retinal cone dystrophy 4 MONDO:0012507

Drugs targeting this protein · 9

PREGABALIN modulator
BEPRIDIL HYDROCHLORIDE blocker
GABAPENTIN ENACARBIL modulator
IMAGABALIN modulator
SULOCTIDIL blocker
PHLOROGLUCINOL blocker
TERODILINE HYDROCHLORIDE blocker
ATAGABALIN modulator
GABAPENTIN modulator

Related proteins · sequence + function similarity

Co-cited proteins · studied together in the literature

Voltage-dependent calcium channel subunit alpha-2/delta-3 1 shared papers
Voltage-dependent L-type calcium channel subunit beta-3 1 shared papers
Voltage-dependent L-type calcium channel subunit alpha-1C 1 shared papers

Literature · 5 cited papers

The full-ORF clone resource of the German cDNA consortium. BMC Genomics · 2007
Mutation in the auxiliary calcium-channel subunit CACNA2D4 causes autosomal recessive cone dystrophy. Am. J. Hum. Genet. · 2006
The finished DNA sequence of human chromosome 12. Nature · 2006
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
Molecular cloning and characterization of the human voltage-gated calcium channel alpha(2)delta-4 subunit. Mol. Pharmacol. · 2002

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