Voltage-dependent calcium channel subunit alpha-2/delta-3
Also known as: CACNA2D3
Function
The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Acts as a regulatory subunit for P/Q-type calcium channel (CACNA1A), N-type (CACNA1B), L-type (CACNA1C OR CACNA1D) but not T-type (CACNA1G) (By similarity).
Classification
- Family (Pfam)
- PF08473 VGCC_alpha2, PF13768 VWA_3, PF08399 VWA_N
- InterPro
- Ca_channel_alpha-2/delta, VDCC_a2/dsu, VWA_N, VWF_A, vWFA_dom_sf
- Functional cluster
- Immunoglobulin-Domain Cell Adhesion Proteins
Gene Ontology · 7
- GO:0098982 GABA-ergic synapse
- GO:0048787 presynaptic active zone membrane
- GO:0005891 voltage-gated calcium channel complex
- GO:0046872 metal ion binding
- GO:0005245 voltage-gated calcium channel activity
- GO:1990314 cellular response to insulin-like growth factor stimulus
- GO:0099174 regulation of presynapse organization
Drugs targeting this protein · 9
- PREGABALIN modulator
- BEPRIDIL HYDROCHLORIDE blocker
- GABAPENTIN ENACARBIL modulator
- IMAGABALIN modulator
- SULOCTIDIL blocker
- PHLOROGLUCINOL blocker
- TERODILINE HYDROCHLORIDE blocker
- ATAGABALIN modulator
- GABAPENTIN modulator
Related proteins · sequence + function similarity
- Voltage-dependent calcium channel subunit alpha-2/delta-3 1.00
- Voltage-dependent calcium channel subunit alpha-2/delta-3 1.00
- Voltage-dependent calcium channel subunit alpha-2/delta-4 0.94
- Voltage-dependent calcium channel subunit alpha-2/delta-4 0.94
- Voltage-dependent calcium channel unc-36 0.87
- Voltage-dependent calcium channel unc-36 0.86
- Voltage-dependent calcium channel subunit alpha-2/delta-1 0.74
- VWFA and cache domain-containing protein 1 0.72
- Voltage-dependent calcium channel subunit alpha-2/delta-1 0.71
- VWFA and cache domain-containing protein 1 0.71
- Voltage-dependent calcium channel subunit alpha-2/delta-2 0.70
- Voltage-dependent calcium channel subunit alpha-2/delta-2 0.70
Co-cited proteins · studied together in the literature
- Voltage-dependent calcium channel subunit alpha-2/delta-4 1 shared papers
- Voltage-dependent calcium channel subunit alpha-2/delta-3 1 shared papers
- Voltage-dependent calcium channel subunit alpha-2/delta-2 1 shared papers
- Voltage-dependent L-type calcium channel subunit beta-3 1 shared papers
- Voltage-dependent L-type calcium channel subunit alpha-1C 1 shared papers
Literature · 4 cited papers
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
- Molecular cloning and characterization of the human voltage-gated calcium channel alpha(2)delta-4 subunit. Mol. Pharmacol. · 2002
- Tissue-specific expression and gabapentin-binding properties of calcium channel alpha2delta subunit subtypes. J. Membr. Biol. · 2001
- Cloning a calcium channel alpha2delta-3 subunit gene from a putative tumor suppressor gene region at chromosome 3p21.1 in conventional renal cell carcinoma. Gene · 2001
A document in the lmmol reference corpus — open public data (UniProt, GO, PDB, the literature graph) rendered as a single cross-linked page. Hover any link to preview its target.