Delta-type opioid receptor
Also known as: OPRD, OPRD1
Function
G protein-coupled receptor that functions as a receptor for endogenous enkephalins and for a subset of other opioids. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain and in opiate-mediated analgesia. Plays a role in developing analgesic tolerance to morphine.
Classification
- Family (Pfam)
- PF00001 7tm_1
- InterPro
- Delta_opi_rcpt, GPCR_Rhodpsn, GPCR_Rhodpsn_7TM, Opioid_rcpt
- Functional cluster
- Membrane Transporters & GPCRs
Experimental structures · PDB · 11
- 4N6H X-ray 1.80A
- 4RWA X-ray 3.28A
- 4RWD X-ray 2.70A
- 6PT2 X-ray 2.80A
- 6PT3 X-ray 3.30A
- 8F7S EM 3.00A
- 8Y45 EM 3.45A
- 8Y71 EM 2.97A
- 9CGJ EM 2.80A
- 9CGK EM 2.62A
- 9YDP EM 1.95A
A predicted model is available from AlphaFold.
Gene Ontology · 29
- GO:0043679 axon terminus
- GO:0032590 dendrite membrane
- GO:0043005 neuron projection
- GO:0098992 neuronal dense core vesicle
- GO:0005886 plasma membrane
- GO:0098839 postsynaptic density membrane
- GO:0042734 presynaptic membrane
- GO:0097444 spine apparatus
- GO:0030672 synaptic vesicle membrane
- GO:0038046 G protein-coupled enkephalin receptor activity
- GO:0004985 G protein-coupled opioid receptor activity
- GO:0042923 neuropeptide binding
- GO:0033612 receptor serine/threonine kinase binding
- GO:0071363 cellular response to growth factor stimulus
- GO:0071456 cellular response to hypoxia
- GO:0097237 cellular response to toxic substance
- GO:0042755 eating behavior
- GO:0038003 G protein-coupled opioid receptor signaling pathway
- GO:0007186 G protein-coupled receptor signaling pathway
- GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
- GO:0006955 immune response
- GO:0010629 negative regulation of gene expression
- GO:0031333 negative regulation of protein-containing complex assembly
- GO:0007218 neuropeptide signaling pathway
- GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway
- GO:0051924 regulation of calcium ion transport
- GO:0051881 regulation of mitochondrial membrane potential
- GO:0045471 response to ethanol
- GO:0035094 response to nicotine
Drugs targeting this protein · 19
- OXYMORPHONE HYDROCHLORIDE agonist
- NALBUPHINE HYDROCHLORIDE agonist
- NALTREXONE HYDROCHLORIDE antagonist
- NALOXONE HYDROCHLORIDE antagonist
- NALTREXONE antagonist
- AZD-7268 agonist
- ONDELOPRAN antagonist
- SAMIDORPHAN L-MALATE partial agonist
- CEBRANOPADOL agonist
- BENZHYDROCODONE HYDROCHLORIDE agonist
- DEXTROMORAMIDE agonist
- HYDROCODONE BITARTRATE agonist
- AXOMADOL agonist
- CODEINE SULFATE agonist
- ADL-5747 agonist
- ADL-5859 agonist
- NALMEFENE HYDROCHLORIDE DIHYDRATE antagonist
- NALOXONE HYDROCHLORIDE DIHYDRATE antagonist
- CODEINE PHOSPHATE agonist
Related proteins · sequence + function similarity
- Delta-type opioid receptor 0.99
- Delta-type opioid receptor 0.99
- Nociceptin receptor 0.93
- Nociceptin receptor 0.92
- Kappa-type opioid receptor 0.92
- Somatostatin receptor type 1 0.91
- Somatostatin receptor type 1 0.91
- Somatostatin receptor type 1 0.91
- Nociceptin receptor 0.91
- Somatostatin receptor type 1 0.91
- Nociceptin receptor 0.90
- Nociceptin receptor 0.90
Co-cited proteins · studied together in the literature
- G protein-coupled receptor-associated sorting protein 1 2 shared papers
- G protein-coupled receptor-associated sorting protein 1 1 shared papers
- G protein-coupled receptor-associated sorting protein 2 1 shared papers
- D(4) dopamine receptor 1 shared papers
- Calcitonin receptor 1 shared papers
- Muscarinic acetylcholine receptor M1 1 shared papers
- Beta-2 adrenergic receptor 1 shared papers
Literature · 9 cited papers
- Expression and localization of opioid receptors during the maturation of human oocytes. Reprod. BioMed. Online · 2012
- Cys-27 variant of human delta-opioid receptor modulates maturation and cell surface delivery of Phe-27 variant via heteromerization. J. Biol. Chem. · 2012
- The DNA sequence and biological annotation of human chromosome 1. Nature · 2006
- Identification of a novel family of G protein-coupled receptor associated sorting proteins. J. Neurochem. · 2004
- Opioid receptor random mutagenesis reveals a mechanism for G protein-coupled receptor activation. Nat. Struct. Biol. · 2003
- Modulation of postendocytic sorting of G protein-coupled receptors. Science · 2002
- Variant detection at the delta opioid receptor (OPRD1) locus and population genetics of a novel variant affecting protein sequence. Hum. Genet. · 2000
- Identification of a human delta opioid receptor: cloning and expression. Life Sci. · 1994
- The human delta-opioid receptor: genomic organization, cDNA cloning, functional expression, and distribution in human brain. Mol. Pharmacol. · 1994
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