Muscarinic acetylcholine receptor M1

Function

The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.

Classification

Family (Pfam)

PF00001 7tm_1

InterPro

GPCR_Rhodpsn, GPCR_Rhodpsn_7TM, Musac_Ach_M1_rcpt, Musac_Ach_rcpt

Functional cluster

G Protein-Coupled Receptors

Experimental structures · PDB · 7

• 5CXV X-ray 2.70A
• 6OIJ EM 3.30A
• 6WJC X-ray 2.55A
• 6ZFZ X-ray 2.17A
• 6ZG4 X-ray 2.33A
• 6ZG9 X-ray 2.50A
• 9JEA EM 3.40A

A predicted model is available from AlphaFold.

Gene Ontology · 30

• GO:0043679 axon terminus
• GO:0098981 cholinergic synapse
• GO:0030425 dendrite
• GO:0098978 glutamatergic synapse
• GO:0016020 membrane
• GO:0005886 plasma membrane
• GO:0098839 postsynaptic density membrane
• GO:0042734 presynaptic membrane
• GO:0098685 Schaffer collateral - CA1 synapse
• GO:0045202 synapse
• GO:0016907 G protein-coupled acetylcholine receptor activity
• GO:0004435 phosphatidylinositol-4,5-bisphosphate phospholipase C activity
• GO:0007197 adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway
• GO:0007268 chemical synaptic transmission
• GO:0050890 cognition
• GO:0007213 G protein-coupled acetylcholine receptor signaling pathway
• GO:0007186 G protein-coupled receptor signaling pathway
• GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
• GO:0007399 nervous system development
• GO:0007274 neuromuscular synaptic transmission
• GO:0007207 phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway
• GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway
• GO:0090316 positive regulation of intracellular protein transport
• GO:0043270 positive regulation of monoatomic ion transport
• GO:0099170 postsynaptic modulation of chemical synaptic transmission
• GO:0060251 regulation of glial cell proliferation
• GO:0040012 regulation of locomotion
• GO:0060078 regulation of postsynaptic membrane potential
• GO:0046541 saliva secretion
• GO:0007165 signal transduction

Drugs targeting this protein · 41

• TRIHEXYPHENIDYL HYDROCHLORIDE antagonist
• PILOCARPINE HYDROCHLORIDE agonist
• ISOPROPAMIDE IODIDE antagonist
• BENZTROPINE MESYLATE antagonist
• METHIXENE HYDROCHLORIDE antagonist
• DICYCLOMINE HYDROCHLORIDE antagonist
• TRIDIHEXETHYL CHLORIDE antagonist
• CYCRIMINE HYDROCHLORIDE antagonist
• DIPHEMANIL METHYLSULFATE antagonist
• OXYPHENCYCLIMINE HYDROCHLORIDE antagonist
• OXYPHENONIUM BROMIDE antagonist
• CLIDINIUM BROMIDE antagonist
• ETHOPROPAZINE HYDROCHLORIDE antagonist
• GLYCOPYRRONIUM BROMIDE antagonist
• BIPERIDEN HYDROCHLORIDE antagonist
• BIPERIDEN LACTATE antagonist
• PROPANTHELINE BROMIDE antagonist
• METHSCOPOLAMINE BROMIDE antagonist
• MINAPRINE HYDROCHLORIDE agonist
• DIPHENIDOL HYDROCHLORIDE antagonist
• ANISOTROPINE METHYLBROMIDE antagonist
• HEXOCYCLIUM METHYLSULFATE antagonist
• MEPENZOLATE BROMIDE antagonist
• PROCYCLIDINE HYDROCHLORIDE antagonist
• TALSACLIDINE agonist
• ATROPINE SULFATE antagonist
• XANOMELINE agonist
• CEVIMELINE HYDROCHLORIDE agonist
• DAROTROPIUM BROMIDE antagonist
• XANOMELINE TARTRATE agonist
• MINAPRINE agonist
• AFACIFENACIN antagonist
• SOFPIRONIUM BROMIDE inhibitor
• GLYCOPYRRONIUM TOSYLATE inhibitor
• MK-7622 positive allosteric modulator
• TAK-071 positive allosteric modulator
• ATROPINE antagonist
• TERODILINE HYDROCHLORIDE antagonist
• PILOCARPINE agonist
• SCOPOLAMINE antagonist
• PIRENZEPINE antagonist

Related proteins · sequence + function similarity

• Muscarinic acetylcholine receptor M1 1.00
• Muscarinic acetylcholine receptor M1 1.00
• Muscarinic acetylcholine receptor M1 1.00
• Muscarinic acetylcholine receptor M1 1.00
• Muscarinic acetylcholine receptor M1 1.00
• Muscarinic acetylcholine receptor M5 0.87
• Muscarinic acetylcholine receptor M5 0.87
• Muscarinic acetylcholine receptor M5 0.87
• Muscarinic acetylcholine receptor M5 0.87
• Histamine H1 receptor 0.85
• Muscarinic acetylcholine receptor M5 0.84
• Muscarinic acetylcholine receptor M5 0.83

Co-cited proteins · studied together in the literature

• Muscarinic toxin 7 1 shared papers
• Muscarinic acetylcholine receptor M3 2 shared papers
• BOS complex subunit TMEM147 1 shared papers
• Muscarinic acetylcholine receptor M4 1 shared papers
• Delta-type opioid receptor 1 shared papers
• G protein-coupled receptor-associated sorting protein 1 1 shared papers
• G protein-coupled receptor-associated sorting protein 2 1 shared papers
• Muscarinic acetylcholine receptor M2 1 shared papers
• Calcitonin receptor 1 shared papers
• G protein-coupled receptor-associated sorting protein 1 1 shared papers
• Muscarinic acetylcholine receptor M3 1 shared papers
• BOS complex subunit TMEM147 1 shared papers

Literature · 9 cited papers

• Structure and selectivity engineering of the M1 muscarinic receptor toxin complex. Science · 2020
• Regulation of M(3) muscarinic receptor expression and function by transmembrane protein 147. Mol. Pharmacol. · 2011
• Human chromosome 11 DNA sequence and analysis including novel gene identification. Nature · 2006
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
• Identification of a novel family of G protein-coupled receptor associated sorting proteins. J. Neurochem. · 2004
• Sequence of the gene encoding the human M1 muscarinic acetylcholine receptor. Nucleic Acids Res. · 1987
• Distinct primary structures, ligand-binding properties and tissue-specific expression of four human muscarinic acetylcholine receptors. EMBO J. · 1987
• Isolation of the human ml (Hml) muscarinic acetylcholine receptor gene by PCR amplification. Nucleic Acids Res. · 1990
• Mutational analysis of third cytoplasmic loop domains in G-protein coupling of the HM1 muscarinic receptor. Biochem. Biophys. Res. Commun. · 1992