Calcitonin receptor

UniProt P30988 Organism Homo sapiens Gene CALCR

Also known as: CALCR

Function

G protein-coupled receptor activated by ligand peptides amylin (IAPP), calcitonin (CT/CALCA) and calcitonin gene-related peptide type 1 (CGRP1/CALCA). CALCR interacts with receptor-activity-modifying proteins RAMP1, 2 and 3 to form receptor complexes AMYR1, 2 and 3, respectively. IAPP, CT and CGRP1 activate CALCR and AMYRs with distinct modes of receptor activation resulting in specific phenotypes. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors. Activates cAMP-dependent pathway.

Classification

Family (Pfam): PF00002 7tm_2, PF02793 HRM
InterPro: GPCR_2, GPCR_2-like_7TM, GPCR_2_calcitonin_rcpt, GPCR_2_calcitonin_rcpt_fam, GPCR_2_extracell_dom_sf, GPCR_2_extracellular_dom, GPCR_2_secretin-like, GPCR_2_secretin-like_CS
Functional cluster: G Protein-Coupled Receptors

Experimental structures · PDB · 30

5II0 X-ray 2.10A
5UZ7 EM 4.10A
6NIY EM 3.34A
6PFO X-ray 1.78A
6PGQ X-ray 2.85A
7TYF EM 2.20A
7TYH EM 3.30A
7TYI EM 3.30A
7TYL EM 3.30A
7TYN EM 2.60A
7TYO EM 2.70A
7TYW EM 3.00A
… and 18 more

A predicted model is available from AlphaFold.

Gene Ontology · 29

Drugs targeting this protein · 4

Related proteins · sequence + function similarity

Co-cited proteins · studied together in the literature

Receptor activity-modifying protein 1 2 shared papers
Calcitonin gene-related peptide 1 1 shared papers
Delta-type opioid receptor 1 shared papers
G protein-coupled receptor-associated sorting protein 1 1 shared papers
G protein-coupled receptor-associated sorting protein 2 1 shared papers
G protein-coupled receptor-associated sorting protein 1 1 shared papers
Muscarinic acetylcholine receptor M1 1 shared papers
Receptor activity-modifying protein 3 1 shared papers
Islet amyloid polypeptide 1 shared papers
Receptor activity-modifying protein 2 1 shared papers
Calcitonin 1 shared papers

Literature · 23 cited papers

Cryo-EM Structure of the Human Amylin 1 Receptor in Complex with CGRP and Gs Protein. Biochemistry · 2024
A structural basis for amylin receptor phenotype. Science · 2022
Calcitonin Receptor N-Glycosylation Enhances Peptide Hormone Affinity by Controlling Receptor Dynamics. J. Mol. Biol. · 2020
Receptor activity-modifying protein-dependent impairment of calcitonin receptor splice variant Delta(1-47)hCT((a)) function. Br. J. Pharmacol. · 2013
Molecular characterization of two novel isoforms of the human calcitonin receptor. Gene · 2004
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
Signal peptide prediction based on analysis of experimentally verified cleavage sites. Protein Sci. · 2004
Identification of a novel family of G protein-coupled receptor associated sorting proteins. J. Neurochem. · 2004
Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat. Genet. · 2004
The DNA sequence of human chromosome 7. Nature · 2003
Human chromosome 7: DNA sequence and biology. Science · 2003
Multiple promoters regulate human calcitonin receptor gene expression. Biochem. Biophys. Res. Commun. · 2000
… and 11 more in the literature graph

A document in the lmmol reference corpus — open public data (UniProt, GO, PDB, the literature graph) rendered as a single cross-linked page. Hover any link to preview its target.