Receptor activity-modifying protein 3
Also known as: RAMP3
Function
Accessory protein that interacts with and modulates the function of G protein-coupled receptors including calcitonin gene-related peptide type 1 receptor (CALCRL), calcitonin receptor (CALCR) and G protein-coupled estrogen receptor 1 (GPER1). Required for the transport of CALCRL and GPER1 receptors to the plasma membrane. Plays a role in cardioprotection by reducing cardiac hypertrophy and perivascular fibrosis in a GPER1-dependent manner. Together with CALCRL, form a receptor complex for adrenomedullin/ADM and intermedin/ADM2. Together with CALCR, act as a receptor complex for amylin/IAPP.
Classification
- Family (Pfam)
- PF04901 RAMP
- InterPro
- RAMP, RAMP_sf
- Functional cluster
- Prenyltransferases & Cell-Wall Biosynthesis Enzymes
Experimental structures · PDB · 7
A predicted model is available from AlphaFold.
Gene Ontology · 33
- GO:1903143 adrenomedullin receptor complex
- GO:0150058 amylin receptor complex 3
- GO:0009986 cell surface
- GO:0005764 lysosome
- GO:0005886 plasma membrane
- GO:0043235 receptor complex
- GO:0001605 adrenomedullin receptor activity
- GO:0097643 amylin receptor activity
- GO:0001540 amyloid-beta binding
- GO:0015026 coreceptor activity
- GO:0030545 signaling receptor regulator activity
- GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway
- GO:1990410 adrenomedullin receptor signaling pathway
- GO:0150061 amylin receptor 3 signaling pathway
- GO:0097647 amylin receptor signaling pathway
- GO:0006816 calcium ion transport
- GO:0071392 cellular response to estradiol stimulus
- GO:0032870 cellular response to hormone stimulus
- GO:0007186 G protein-coupled receptor signaling pathway
- GO:0086103 G protein-coupled receptor signaling pathway involved in heart process
- GO:0006886 intracellular protein transport
- GO:0050850 positive regulation of calcium-mediated signaling
- GO:0141163 positive regulation of cAMP/PKA signal transduction
- GO:0070374 positive regulation of ERK1 and ERK2 cascade
- GO:0010628 positive regulation of gene expression
- GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
- GO:1903078 positive regulation of protein localization to plasma membrane
- GO:0001921 positive regulation of receptor recycling
- GO:0072659 protein localization to plasma membrane
- GO:0015031 protein transport
- GO:0031623 receptor internalization
- GO:0008277 regulation of G protein-coupled receptor signaling pathway
- GO:1904645 response to amyloid-beta
Drugs targeting this protein · 1
- PRAMLINTIDE ACETATE agonist
Related proteins · sequence + function similarity
- Receptor activity-modifying protein 3 0.98
- Receptor activity-modifying protein 3 0.97
- Receptor activity-modifying protein 3 0.95
- Receptor activity-modifying protein 3 0.94
- Receptor activity-modifying protein 2 0.83
- Receptor activity-modifying protein 2 0.82
- Receptor activity-modifying protein 2 0.80
- Receptor activity-modifying protein 2 0.79
- Receptor activity-modifying protein 1 0.78
- Receptor activity-modifying protein 1 0.75
- Receptor activity-modifying protein 1 0.75
- Receptor activity-modifying protein 1 0.73
Co-cited proteins · studied together in the literature
- Receptor activity-modifying protein 2 3 shared papers
- Pro-adrenomedullin 2 shared papers
- Receptor activity-modifying protein 3 1 shared papers
- Calcitonin gene-related peptide type 1 receptor 2 shared papers
- Receptor activity-modifying protein 1 2 shared papers
- Protein ADM2 1 shared papers
- G protein-coupled estrogen receptor 1 1 shared papers
- Calcitonin receptor 1 shared papers
- G protein-coupled estrogen receptor 1 1 shared papers
- Islet amyloid polypeptide 1 shared papers
- Calcitonin gene-related peptide 2 1 shared papers
- Calcitonin 1 shared papers
Literature · 6 cited papers
- A structural basis for amylin receptor phenotype. Science · 2022
- Structure and Dynamics of Adrenomedullin Receptors AM1 and AM2 Reveal Key Mechanisms in the Control of Receptor Phenotype by Receptor Activity-Modifying Proteins. ACS Pharmacol. Transl. Sci. · 2020
- G-protein-coupled receptor 30 interacts with receptor activity-modifying protein 3 and confers sex-dependent cardioprotection. J. Mol. Endocrinol. · 2013
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
- The DNA sequence of human chromosome 7. Nature · 2003
- RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor. Nature · 1998
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