Muscarinic acetylcholine receptor M4
Also known as: CHRM4
Function
The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is inhibition of adenylate cyclase.
Classification
- Family (Pfam)
- PF00001 7tm_1
- InterPro
- GPCR_Rhodpsn, GPCR_Rhodpsn_7TM, Musac_Ach_M4_rcpt, Musac_Ach_rcpt
- Functional cluster
- Membrane Transporters & GPCRs
Experimental structures · PDB · 36
- 5DSG X-ray 2.60A
- 6D9H EM 3.60A
- 6KP6 X-ray 3.00A
- 7LD3 EM 3.20A
- 7LD4 EM 3.30A
- 7TRK EM 2.80A
- 7TRP EM 2.40A
- 7TRQ EM 2.50A
- 7TRS EM 2.80A
- 7V68 EM 3.40A
- 7V69 EM 3.40A
- 7V6A EM 3.60A
- … and 24 more
A predicted model is available from AlphaFold.
Gene Ontology · 12
- GO:0030425 dendrite
- GO:0005886 plasma membrane
- GO:0045211 postsynaptic membrane
- GO:0045202 synapse
- GO:0016907 G protein-coupled acetylcholine receptor activity
- GO:0007197 adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway
- GO:0007166 cell surface receptor signaling pathway
- GO:0007268 chemical synaptic transmission
- GO:0007213 G protein-coupled acetylcholine receptor signaling pathway
- GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
- GO:0040012 regulation of locomotion
- GO:0007165 signal transduction
Drugs targeting this protein · 7
- XANOMELINE agonist
- DAROTROPIUM BROMIDE antagonist
- XANOMELINE TARTRATE agonist
- AFACIFENACIN antagonist
- SOFPIRONIUM BROMIDE inhibitor
- GLYCOPYRRONIUM TOSYLATE inhibitor
- TERODILINE HYDROCHLORIDE antagonist
Related proteins · sequence + function similarity
- Muscarinic acetylcholine receptor M4 1.00
- Muscarinic acetylcholine receptor M4 1.00
- Muscarinic acetylcholine receptor M4 0.96
- Muscarinic acetylcholine receptor M4 0.94
- Muscarinic acetylcholine receptor M2 0.91
- Muscarinic acetylcholine receptor M2 0.90
- Muscarinic acetylcholine receptor M2 0.90
- Muscarinic acetylcholine receptor M2 0.89
- Muscarinic acetylcholine receptor M5 0.89
- Muscarinic acetylcholine receptor M5 0.88
- Muscarinic acetylcholine receptor M2 0.88
- Muscarinic acetylcholine receptor M3 0.88
Co-cited proteins · studied together in the literature
- Muscarinic acetylcholine receptor M3 2 shared papers
- Muscarinic acetylcholine receptor M3 2 shared papers
- Muscarinic acetylcholine receptor M4 1 shared papers
- Muscarinic acetylcholine receptor M5 1 shared papers
- Muscarinic acetylcholine receptor M2 2 shared papers
- Muscarinic acetylcholine receptor M1 1 shared papers
- Muscarinic acetylcholine receptor M5 1 shared papers
- Muscarinic acetylcholine receptor M1 1 shared papers
Literature · 4 cited papers
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
- Distinct primary structures, ligand-binding properties and tissue-specific expression of four human muscarinic acetylcholine receptors. EMBO J. · 1987
- Cloning and expression of the human and rat m5 muscarinic acetylcholine receptor genes. Neuron · 1988
- Identification of a family of muscarinic acetylcholine receptor genes. Science · 1987
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