Muscarinic acetylcholine receptor M5
Also known as: CHRM5
Function
The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.
Classification
- Family (Pfam)
- PF00001 7tm_1
- InterPro
- GPCR_Rhodpsn, GPCR_Rhodpsn_7TM, Musac_Ach_M5_rcpt, Musac_Ach_rcpt
- Functional cluster
- Membrane Transporters & GPCRs
Experimental structures · PDB · 2
A predicted model is available from AlphaFold.
Gene Ontology · 12
- GO:0030425 dendrite
- GO:0005886 plasma membrane
- GO:0045211 postsynaptic membrane
- GO:0045202 synapse
- GO:0016907 G protein-coupled acetylcholine receptor activity
- GO:0004435 phosphatidylinositol-4,5-bisphosphate phospholipase C activity
- GO:0007197 adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway
- GO:0007268 chemical synaptic transmission
- GO:0007213 G protein-coupled acetylcholine receptor signaling pathway
- GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
- GO:0001696 gastric acid secretion
- GO:0060304 regulation of phosphatidylinositol dephosphorylation
Drugs targeting this protein · 5
- DAROTROPIUM BROMIDE antagonist
- AFACIFENACIN antagonist
- SOFPIRONIUM BROMIDE inhibitor
- GLYCOPYRRONIUM TOSYLATE inhibitor
- TERODILINE HYDROCHLORIDE antagonist
Related proteins · sequence + function similarity
- Muscarinic acetylcholine receptor M5 0.99
- Muscarinic acetylcholine receptor M5 0.99
- Muscarinic acetylcholine receptor M5 0.99
- Muscarinic acetylcholine receptor M5 0.98
- Muscarinic acetylcholine receptor M5 0.98
- Muscarinic acetylcholine receptor M3 0.91
- Muscarinic acetylcholine receptor M3 0.91
- Muscarinic acetylcholine receptor M3 0.91
- Muscarinic acetylcholine receptor M3 0.91
- Muscarinic acetylcholine receptor M3 0.91
- Muscarinic acetylcholine receptor M3 0.91
- Muscarinic acetylcholine receptor M3 0.90
Co-cited proteins · studied together in the literature
- Muscarinic acetylcholine receptor M5 1 shared papers
- Muscarinic acetylcholine receptor M4 1 shared papers
- Muscarinic acetylcholine receptor M3 1 shared papers
- Muscarinic acetylcholine receptor M3 1 shared papers
Literature · 1 cited papers
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