Muscarinic acetylcholine receptor M3

UniProt P20309 Organism Homo sapiens Gene CHRM3

Also known as: CHRM3

Function

The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.

Classification

Family (Pfam): PF00001 7tm_1
InterPro: GPCR_Rhodpsn, GPCR_Rhodpsn_7TM, Musac_Ach_M3_rcpt, Musac_Ach_rcpt
Functional cluster: RRM RNA-Binding & Protein Kinases

Experimental structures · PDB · 5

2CSA NMR
8E9W EM 2.69A
8E9Y EM 2.79A
8E9Z EM 2.69A
8EA0 EM 2.56A

A predicted model is available from AlphaFold.

Gene Ontology · 25

Disease associations

prune belly syndrome MONDO:0007032

Drugs targeting this protein · 48

OXYBUTYNIN CHLORIDE antagonist
ACETYLCHOLINE CHLORIDE agonist
PILOCARPINE HYDROCHLORIDE agonist
ISOPROPAMIDE IODIDE antagonist
CYCLOPENTOLATE HYDROCHLORIDE antagonist
DICYCLOMINE HYDROCHLORIDE antagonist
TROPICAMIDE antagonist
METHACHOLINE CHLORIDE agonist
TRIDIHEXETHYL CHLORIDE antagonist
SOLIFENACIN SUCCINATE antagonist
DIPHEMANIL METHYLSULFATE antagonist
OXYPHENCYCLIMINE HYDROCHLORIDE antagonist
OXYPHENONIUM BROMIDE antagonist
DARIFENACIN HYDROBROMIDE antagonist
CLIDINIUM BROMIDE antagonist
GLYCOPYRRONIUM BROMIDE antagonist
FESOTERODINE FUMARATE antagonist
OXYBUTYNIN antagonist
PROPANTHELINE BROMIDE antagonist
METHSCOPOLAMINE BROMIDE antagonist
CARBACHOL agonist
ANISOTROPINE METHYLBROMIDE antagonist
HEXOCYCLIUM METHYLSULFATE antagonist
TOLTERODINE TARTRATE antagonist
MEPENZOLATE BROMIDE antagonist
BETHANECHOL CHLORIDE agonist
TARAFENACIN antagonist
AZD-9164 antagonist
TALSACLIDINE partial agonist
IPRATROPIUM BROMIDE antagonist
ATROPINE SULFATE antagonist
CEVIMELINE HYDROCHLORIDE agonist
DAROTROPIUM BROMIDE antagonist
BATEFENTEROL antagonist
TROSPIUM CHLORIDE antagonist
AFACIFENACIN antagonist
TIOTROPIUM BROMIDE antagonist
SOFPIRONIUM BROMIDE inhibitor
GLYCOPYRRONIUM TOSYLATE inhibitor
REVEFENACIN antagonist
LAS190792 antagonist
NAVAFENTEROL antagonist
ATROPINE antagonist
UMECLIDINIUM BROMIDE antagonist
IMIDAFENACIN antagonist
TERODILINE HYDROCHLORIDE antagonist
PILOCARPINE agonist
ACLIDINIUM BROMIDE antagonist

Related proteins · sequence + function similarity

Co-cited proteins · studied together in the literature

Muscarinic acetylcholine receptor M4 2 shared papers
Solute carrier organic anion transporter family member 1A2 1 shared papers
Muscarinic acetylcholine receptor M1 2 shared papers
Muscarinic acetylcholine receptor M5 1 shared papers
BOS complex subunit TMEM147 1 shared papers
Muscarinic acetylcholine receptor M5 1 shared papers
Muscarinic acetylcholine receptor M2 1 shared papers
Muscarinic acetylcholine receptor M3 1 shared papers
Muscarinic acetylcholine receptor M3 1 shared papers
BOS complex subunit TMEM147 1 shared papers
Vasopressin V2 receptor 1 shared papers

Literature · 11 cited papers

The muscarinic M3 acetylcholine receptor exists as two differently sized complexes at the plasma membrane. Biochem. J. · 2013
Muscarinic acetylcholine receptor M3 mutation causes urinary bladder disease and a prune-belly-like syndrome. Am. J. Hum. Genet. · 2011
Regulation of M(3) muscarinic receptor expression and function by transmembrane protein 147. Mol. Pharmacol. · 2011
The DNA sequence and biological annotation of human chromosome 1. Nature · 2006
Identification and structural determination of the M(3) muscarinic acetylcholine receptor basolateral sorting signal. J. Biol. Chem. · 2005
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
Human-specific amino acid changes found in 103 protein-coding genes. Mol. Biol. Evol. · 2004
Antisense promoter of human L1 retrotransposon drives transcription of adjacent cellular genes. Mol. Cell. Biol. · 2001
Mutation of carboxyl-terminal threonine residues in human M3 muscarinic acetylcholine receptor modulates the extent of sequestration and desensitization. Mol. Pharmacol. · 1995
Distinct primary structures, ligand-binding properties and tissue-specific expression of four human muscarinic acetylcholine receptors. EMBO J. · 1987
Cloning and expression of the human and rat m5 muscarinic acetylcholine receptor genes. Neuron · 1988

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