Vasopressin V2 receptor
Also known as: ADHR, AVPR2, DIR, DIR3, V2R
Function
G protein-coupled receptor for arginine vasopressin, an antidiuretic that promotes renal water reabsorption. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (cAMP). AVPR2 is coupled to G(s) G alpha proteins and mediates activation of adenylate cyclase activity.
Classification
- Family (Pfam)
- PF00001 7tm_1
- InterPro
- GPCR_Rhodpsn, GPCR_Rhodpsn_7TM, Vasoprsn_rcpt, Vprsn_rcpt_V2
- Functional cluster
- Nucleic Acid Metabolism & Repair Enzymes
Experimental structures · PDB · 35
- 4JQI X-ray 2.60A
- 6NI2 EM 4.00A
- 6U1N EM 4.00A
- 7BB6 EM 4.20A
- 7BB7 EM 4.40A
- 7DF9 X-ray 3.17A
- 7DFA X-ray 2.54A
- 7DFB X-ray 3.28A
- 7DFC X-ray 2.49A
- 7DW9 EM 2.60A
- 7KH0 EM 2.80A
- 7R0C EM 4.73A
- … and 23 more
A predicted model is available from AlphaFold.
Gene Ontology · 25
- GO:0030669 clathrin-coated endocytic vesicle membrane
- GO:0030139 endocytic vesicle
- GO:0005783 endoplasmic reticulum
- GO:0005768 endosome
- GO:0005794 Golgi apparatus
- GO:0016020 membrane
- GO:0048471 perinuclear region of cytoplasm
- GO:0005886 plasma membrane
- GO:0005000 vasopressin receptor activity
- GO:0007190 activation of adenylate cyclase activity
- GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway
- GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway
- GO:0032870 cellular response to hormone stimulus
- GO:0007186 G protein-coupled receptor signaling pathway
- GO:0007599 hemostasis
- GO:0008285 negative regulation of cell population proliferation
- GO:0008284 positive regulation of cell population proliferation
- GO:0010628 positive regulation of gene expression
- GO:1902533 positive regulation of intracellular signal transduction
- GO:0003084 positive regulation of systemic arterial blood pressure
- GO:0045907 positive regulation of vasoconstriction
- GO:0001992 regulation of systemic arterial blood pressure by vasopressin
- GO:0070295 renal water absorption
- GO:0003092 renal water retention
- GO:0021537 telencephalon development
Disease associations
- nephrogenic syndrome of inappropriate antidiuresis MONDO:0010356
- diabetes insipidus, nephrogenic, X-linked MONDO:0010581
Drugs targeting this protein · 10
- DESMOPRESSIN ACETATE agonist
- LYPRESSIN agonist
- CONIVAPTAN HYDROCHLORIDE antagonist
- SATAVAPTAN antagonist
- TERLIPRESSIN binding agent
- TOLVAPTAN antagonist
- VASOPRESSIN agonist
- MOZAVAPTAN antagonist
- PECAVAPTAN antagonist
- LIXIVAPTAN antagonist
Neighborhood · nearest proteins
Related proteins · sequence + function similarity
- Vasopressin V2 receptor 0.99
- Vasopressin V2 receptor 0.99
- Vasopressin V2 receptor 0.99
- Vasopressin V2 receptor 0.99
- Vasopressin V2 receptor 0.99
- Vasopressin V1b receptor 0.91
- Vasopressin V1b receptor 0.88
- Gonadotropin-releasing hormone II receptor 0.88
- Vasopressin V1b receptor 0.88
- Gonadotropin-releasing hormone II receptor 0.87
- Gonadotropin-releasing hormone II receptor 0.86
- Probable G protein-coupled receptor 150 0.85
Co-cited proteins · studied together in the literature
- Aquaporin-2 3 shared papers
- Vasopressin-neurophysin 2-copeptin 2 shared papers
- Vasopressin V1a receptor 1 shared papers
- Vasopressin V1b receptor 1 shared papers
- BOS complex subunit TMEM147 1 shared papers
- Muscarinic acetylcholine receptor M3 1 shared papers
- Muscarinic acetylcholine receptor M3 1 shared papers
- Muscarinic acetylcholine receptor M1 1 shared papers
- BOS complex subunit TMEM147 1 shared papers
- Arrestin domain-containing protein 4 1 shared papers
- Muscarinic acetylcholine receptor M2 1 shared papers
- NEDD4-like E3 ubiquitin-protein ligase WWP2 1 shared papers
Literature · 50 cited papers
- Structural snapshots uncover a key phosphorylation motif in GPCRs driving beta-arrestin activation. Mol. Cell · 2023
- Molecular basis of ligand recognition and activation of human V2 vasopressin receptor. Cell Res. · 2021
- Cryo-EM structure of the AVP-vasopressin receptor 2-Gs signaling complex. Cell Res. · 2021
- Mammalian alpha arrestins link activated seven transmembrane receptors to Nedd4 family e3 ubiquitin ligases and interact with beta arrestins. PLoS ONE · 2012
- Regulation of M(3) muscarinic receptor expression and function by transmembrane protein 147. Mol. Pharmacol. · 2011
- Involvement of the V2 vasopressin receptor in adaptation to limited water supply. PLoS ONE · 2009
- The consensus coding sequences of human breast and colorectal cancers. Science · 2006
- Novel mutations underlying nephrogenic diabetes insipidus in Arab families. Genet. Med. · 2006
- Nephrogenic syndrome of inappropriate antidiuresis. N. Engl. J. Med. · 2005
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
- Identification of mutations in the arginine vasopressin receptor 2 gene causing nephrogenic diabetes insipidus in Chinese patients. J. Hum. Genet. · 2002
- Molecular and cellular defects in nephrogenic diabetes insipidus. Pediatr. Nephrol. · 2001
- … and 38 more in the literature graph
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