Vasopressin V1a receptor

Function

Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl-inositol-calcium second messenger system. Has been involved in social behaviors, including affiliation and attachment.

Classification

Family (Pfam)

PF00001 7tm_1, PF08983 V1R_C

InterPro

GPCR_Rhodpsn, GPCR_Rhodpsn_7TM, V1R_C, Vasoprsn_rcpt, Vprs_V1A_rcpt

Functional cluster

Membrane Transporters & GPCRs

Experimental structures · PDB · 1

• 1YTV X-ray 1.80A

A predicted model is available from AlphaFold.

Gene Ontology · 34

• GO:0030139 endocytic vesicle
• GO:0005768 endosome
• GO:0005886 plasma membrane
• GO:0017046 peptide hormone binding
• GO:0005080 protein kinase C binding
• GO:0031894 V1A vasopressin receptor binding
• GO:0005000 vasopressin receptor activity
• GO:0008015 blood circulation
• GO:0019722 calcium-mediated signaling
• GO:0032870 cellular response to hormone stimulus
• GO:0042631 cellular response to water deprivation
• GO:0007186 G protein-coupled receptor signaling pathway
• GO:0006091 generation of precursor metabolites and energy
• GO:0007625 grooming behavior
• GO:0002125 maternal aggressive behavior
• GO:0042711 maternal behavior
• GO:0014902 myotube differentiation
• GO:0007621 negative regulation of female receptivity
• GO:0051970 negative regulation of transmission of nerve impulse
• GO:0030307 positive regulation of cell growth
• GO:0008284 positive regulation of cell population proliferation
• GO:0032849 positive regulation of cellular pH reduction
• GO:0007204 positive regulation of cytosolic calcium ion concentration
• GO:0014049 positive regulation of glutamate secretion
• GO:0010460 positive regulation of heart rate
• GO:0031394 positive regulation of prostaglandin biosynthetic process
• GO:0003084 positive regulation of systemic arterial blood pressure
• GO:0045907 positive regulation of vasoconstriction
• GO:0001992 regulation of systemic arterial blood pressure by vasopressin
• GO:0051412 response to corticosterone
• GO:0035176 social behavior
• GO:0042713 sperm ejaculation
• GO:0021537 telencephalon development
• GO:0150104 transport across blood-brain barrier

Drugs targeting this protein · 10

• DESMOPRESSIN ACETATE agonist
• LYPRESSIN agonist
• CONIVAPTAN HYDROCHLORIDE antagonist
• SELEPRESSIN agonist
• TERLIPRESSIN binding agent
• SRX246 antagonist
• VASOPRESSIN agonist
• RELCOVAPTAN antagonist
• BALOVAPTAN antagonist
• PECAVAPTAN antagonist

Related proteins · sequence + function similarity

• Vasopressin V1a receptor 0.99
• Vasopressin V1a receptor 0.98
• Vasopressin V1a receptor 0.98
• Vasopressin V1a receptor 0.98
• Vasopressin V1a receptor 0.98
• Oxytocin receptor 0.92
• Oxytocin receptor 0.92
• Oxytocin receptor 0.92
• Oxytocin receptor 0.92
• Oxytocin receptor 0.92
• Oxytocin receptor 0.91
• Oxytocin receptor 0.91

Co-cited proteins · studied together in the literature

• Vasopressin V1b receptor 2 shared papers
• Vasopressin V2 receptor 1 shared papers

Literature · 7 cited papers

• A C-terminal segment of the V1R vasopressin receptor is unstructured in the crystal structure of its chimera with the maltose-binding protein. Acta Crystallogr. F · 2005
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
• Transmission disequilibrium testing of arginine vasopressin receptor 1A (AVPR1A) polymorphisms in autism. Mol. Psychiatry · 2002
• Expression of all known vasopressin receptor subtypes by small cell tumors implies a multifaceted role for this neuropeptide. Cancer Res. · 1998
• Functional vasopressin V1 type receptors are present in variant as well as classical forms of small-cell carcinoma. Peptides · 1997
• Molecular cloning, sequencing, and functional expression of a cDNA encoding the human V1a vasopressin receptor. J. Biol. Chem. · 1994
• Cloning, functional expression and tissue distribution of human cDNA for the vascular-type vasopressin receptor. Biochem. Biophys. Res. Commun. · 1994