Vasopressin V1b receptor
Also known as: AVPR1B, AVPR3, VPR3
Function
Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl-inositol-calcium second messenger system.
Classification
- Family (Pfam)
- PF00001 7tm_1
- InterPro
- GPCR_Rhodpsn, GPCR_Rhodpsn_7TM, V1R_C, Vasoprsn_rcpt, Vprs_rcpt_V1B
- Functional cluster
- G Protein-Coupled Receptors
Gene Ontology · 17
- GO:0005768 endosome
- GO:0005794 Golgi apparatus
- GO:0005886 plasma membrane
- GO:0005080 protein kinase C binding
- GO:0005000 vasopressin receptor activity
- GO:0032870 cellular response to hormone stimulus
- GO:0007186 G protein-coupled receptor signaling pathway
- GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway
- GO:0090238 positive regulation of arachidonate secretion
- GO:0007204 positive regulation of cytosolic calcium ion concentration
- GO:0060732 positive regulation of inositol phosphate biosynthetic process
- GO:0043410 positive regulation of MAPK cascade
- GO:0045907 positive regulation of vasoconstriction
- GO:0042127 regulation of cell population proliferation
- GO:0001992 regulation of systemic arterial blood pressure by vasopressin
- GO:0046718 symbiont entry into host cell
- GO:0150104 transport across blood-brain barrier
Drugs targeting this protein · 5
- DESMOPRESSIN ACETATE agonist
- LYPRESSIN agonist
- TERLIPRESSIN binding agent
- VASOPRESSIN agonist
- NELIVAPTAN antagonist
Related proteins · sequence + function similarity
- Vasopressin V1b receptor 0.98
- Vasopressin V1b receptor 0.98
- Vasopressin V2 receptor 0.92
- Vasopressin V2 receptor 0.92
- Vasopressin V2 receptor 0.92
- Vasopressin V2 receptor 0.92
- Vasopressin V2 receptor 0.91
- Gonadotropin-releasing hormone II receptor 0.90
- Vasopressin V2 receptor 0.90
- Gonadotropin-releasing hormone II receptor 0.90
- Gonadotropin-releasing hormone II receptor 0.90
- Oxytocin receptor 0.88
Co-cited proteins · studied together in the literature
- Vasopressin V1a receptor 2 shared papers
- Vasopressin V2 receptor 1 shared papers
- Type-1 angiotensin II receptor 1 shared papers
- Vasopressin-neurophysin 2-copeptin 1 shared papers
- Dynamin-2 1 shared papers
- Angiotensin-converting enzyme 2 1 shared papers
Literature · 8 cited papers
- Soluble ACE2-mediated cell entry of SARS-CoV-2 via interaction with proteins related to the renin-angiotensin system. Cell · 2021
- Evidence of an association between the vasopressin V1b receptor gene (AVPR1B) and childhood-onset mood disorders. Arch. Gen. Psychiatry · 2007
- The DNA sequence and biological annotation of human chromosome 1. Nature · 2006
- Nucleotide sequence and structural organization of the human vasopressin pituitary receptor (V3) gene. Gene · 2000
- Expression of all known vasopressin receptor subtypes by small cell tumors implies a multifaceted role for this neuropeptide. Cancer Res. · 1998
- Functional vasopressin V1 type receptors are present in variant as well as classical forms of small-cell carcinoma. Peptides · 1997
- Molecular cloning and functional expression of a cDNA encoding the human V1b vasopressin receptor. J. Biol. Chem. · 1994
- Cloning and characterization of the human V3 pituitary vasopressin receptor. FEBS Lett. · 1994
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