Type-1 angiotensin II receptor
Also known as: AGTR1, AGTR1A, AGTR1B, AT2R1, AT2R1B
Function
Receptor for angiotensin II, a vasoconstricting peptide, which acts as a key regulator of blood pressure and sodium retention by the kidney. The activated receptor in turn couples to G-alpha proteins G(q) (GNAQ, GNA11, GNA14 or GNA15) and thus activates phospholipase C and increases the cytosolic Ca(2+) concentrations, which in turn triggers cellular responses such as stimulation of protein kinase C.
Classification
- Family (Pfam)
- PF00001 7tm_1
- InterPro
- ATII_AT1_rcpt, ATII_rcpt, CCR1-9-like, GPCR_Rhodpsn, GPCR_Rhodpsn_7TM
- Functional cluster
- G Protein-Coupled Receptors
Experimental structures · PDB · 8
- 4YAY X-ray 2.90A
- 4ZUD X-ray 2.80A
- 6DO1 X-ray 2.90A
- 6OS0 X-ray 2.90A
- 6OS1 X-ray 2.79A
- 6OS2 X-ray 2.70A
- 8TH3 EM 3.00A
- 8TH4 EM 3.30A
A predicted model is available from AlphaFold.
Gene Ontology · 33
- GO:0016020 membrane
- GO:0005886 plasma membrane
- GO:0001596 angiotensin type I receptor activity
- GO:0004945 angiotensin type II receptor activity
- GO:0031711 bradykinin receptor binding
- GO:0046982 protein heterodimerization activity
- GO:0038166 angiotensin-activated signaling pathway
- GO:0097746 blood vessel diameter maintenance
- GO:0019722 calcium-mediated signaling
- GO:0060326 cell chemotaxis
- GO:0007186 G protein-coupled receptor signaling pathway
- GO:0006954 inflammatory response
- GO:0001822 kidney development
- GO:0034374 low-density lipoprotein particle remodeling
- GO:0002034 maintenance of blood vessel diameter homeostasis by renin-angiotensin
- GO:0086097 phospholipase C-activating angiotensin-activated signaling pathway
- GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway
- GO:1903589 positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis
- GO:0090205 positive regulation of cholesterol metabolic process
- GO:0007204 positive regulation of cytosolic calcium ion concentration
- GO:0050729 positive regulation of inflammatory response
- GO:0010744 positive regulation of macrophage derived foam cell differentiation
- GO:2000379 positive regulation of reactive oxygen species metabolic process
- GO:0008217 regulation of blood pressure
- GO:0001558 regulation of cell growth
- GO:0042127 regulation of cell population proliferation
- GO:0050727 regulation of inflammatory response
- GO:0035813 regulation of renal sodium excretion
- GO:0003081 regulation of systemic arterial blood pressure by renin-angiotensin
- GO:0019229 regulation of vasoconstriction
- GO:0002018 renin-angiotensin regulation of aldosterone production
- GO:0007266 Rho protein signal transduction
- GO:0046718 symbiont entry into host cell
Disease associations
- renal tubular dysgenesis of genetic origin MONDO:0009970
Drugs targeting this protein · 19
- CANDESARTAN CILEXETIL antagonist
- CANDESARTAN antagonist
- TELMISARTAN antagonist
- VALSARTAN antagonist
- SARALASIN ACETATE antagonist
- OLMESARTAN MEDOXOMIL antagonist
- EPROSARTAN MESYLATE antagonist
- IRBESARTAN antagonist
- OLMESARTAN antagonist
- FIMASARTAN antagonist
- AZILSARTAN KAMEDOXOMIL antagonist
- ANGIOTENSIN II ACETATE agonist
- PRATOSARTAN antagonist
- TRV-120027 antagonist
- TASOSARTAN antagonist
- SPARSENTAN antagonist
- AZILSARTAN antagonist
- IRBESARTAN HYDROCHLORIDE antagonist
- LOSARTAN POTASSIUM antagonist
Related proteins · sequence + function similarity
- Type-1 angiotensin II receptor 1.00
- Type-1 angiotensin II receptor 1.00
- Type-1 angiotensin II receptor 1.00
- Type-1 angiotensin II receptor 1.00
- Type-1 angiotensin II receptor 1.00
- Type-1 angiotensin II receptor 1.00
- Type-1 angiotensin II receptor B 1.00
- Type-1 angiotensin II receptor A 1.00
- Type-1 angiotensin II receptor 1.00
- Type-1 angiotensin II receptor A 1.00
- Type-1 angiotensin II receptor B 0.99
- Type-1 angiotensin II receptor 0.99
Co-cited proteins · studied together in the literature
- Proto-oncogene Mas 2 shared papers
- Angiotensinogen 2 shared papers
- Renin 1 shared papers
- Beta-arrestin-1 1 shared papers
- Vasopressin V1b receptor 1 shared papers
- Alpha-1D adrenergic receptor 1 shared papers
- D(3) dopamine receptor 1 shared papers
- Vasopressin-neurophysin 2-copeptin 1 shared papers
- Angiotensin-converting enzyme 1 shared papers
- Dynamin-2 1 shared papers
- Filamin-A 1 shared papers
- Angiotensin-converting enzyme 2 1 shared papers
Literature · 19 cited papers
- Soluble ACE2-mediated cell entry of SARS-CoV-2 via interaction with proteins related to the renin-angiotensin system. Cell · 2021
- Angiotensin and biased analogs induce structurally distinct active conformations within a GPCR. Science · 2020
- Distinctive Activation Mechanism for Angiotensin Receptor Revealed by a Synthetic Nanobody. Cell · 2019
- G Protein-Coupled Receptors Directly Bind Filamin A with High Affinity and Promote Filamin Phosphorylation. Biochemistry · 2015
- Structural Basis for Ligand Recognition and Functional Selectivity at Angiotensin Receptor. J. Biol. Chem. · 2015
- Structure of the Angiotensin receptor revealed by serial femtosecond crystallography. Cell · 2015
- A strategy for precise and large scale identification of core fucosylated glycoproteins. Mol. Cell. Proteomics · 2009
- Mutations in genes in the renin-angiotensin system are associated with autosomal recessive renal tubular dysgenesis. Nat. Genet. · 2005
- G-protein-coupled receptor Mas is a physiological antagonist of the angiotensin II type 1 receptor. Circulation · 2005
- beta-Arrestin 1 and Galphaq/11 coordinately activate RhoA and stress fiber formation following receptor stimulation. J. Biol. Chem. · 2005
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
- The active state of the AT1 angiotensin receptor is generated by angiotensin II induction. Biochemistry · 1996
- … and 7 more in the literature graph
A document in the lmmol reference corpus — open public data (UniProt, GO, PDB, the literature graph) rendered as a single cross-linked page. Hover any link to preview its target.