Proto-oncogene Mas

Function

G protein-coupled receptor that plays key roles in the renin-angiotensin system (RAS) specifically in the protective, counter-regulatory arm of the RAS. Receptor mainly stimulated by angiotensin 1-7, which is a bioactive metabolite of the angiotensin produced by ACE2. Activation promotes nitric oxide via PI3K/Akt-eNOS pathway. Modulates also the MAPK, ERK1/2, and NF-kappa-B signaling. Positive regulation of AGTR1 levels occurs through activation of the G proteins GNA11 and GNAQ, and stimulation of the protein kinase C signaling cascade. The antagonist effect on AGTR1 function is probably due to AGTR1 being physically altered by MAS1. Acts as functional receptor for CXCL17 and induces chemotactic movement.

Classification

Family (Pfam)

PF00001 7tm_1

InterPro

GPCR_Rhodpsn, GPCR_Rhodpsn_7TM, MRGPCRFAMILY, Proto-oncogene_Mas

Functional cluster

Immunoglobulin & Immune-Response Proteins

Experimental structures · PDB · 1

• 9JLC EM 2.98A

A predicted model is available from AlphaFold.

Gene Ontology · 12

• GO:0005886 plasma membrane
• GO:0001595 angiotensin receptor activity
• GO:0004945 angiotensin type II receptor activity
• GO:0016493 C-C chemokine receptor activity
• GO:0004930 G protein-coupled receptor activity
• GO:0042277 peptide binding
• GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway
• GO:0002033 angiotensin-mediated vasodilation involved in regulation of systemic arterial blood pressure
• GO:0016477 cell migration
• GO:0070098 chemokine-mediated signaling pathway
• GO:0007186 G protein-coupled receptor signaling pathway
• GO:0086097 phospholipase C-activating angiotensin-activated signaling pathway

Drugs targeting this protein · 1

• TALFIRASTIDE agonist

Related proteins · sequence + function similarity

• Proto-oncogene Mas 1.00
• Proto-oncogene Mas 1.00
• Mas-related G protein-coupled receptor member H 0.97
• Mas-related G protein-coupled receptor member H 0.97
• Mas-related G protein-coupled receptor member B2 0.94
• Mas-related G protein-coupled receptor member A4 0.93
• Mas-related G protein-coupled receptor member A7 0.93
• Mas-related G protein-coupled receptor member X1 0.93
• Mas-related G protein-coupled receptor member B1 0.93
• Mas-related G protein-coupled receptor member A8 0.93
• Mas-related G protein-coupled receptor member B4 0.93
• Mas-related G protein-coupled receptor member A 0.93

Co-cited proteins · studied together in the literature

• Type-1 angiotensin II receptor 2 shared papers
• Mas-related G protein-coupled receptor member X1 1 shared papers
• Mas-related G protein-coupled receptor member X2 1 shared papers
• Alpha-1D adrenergic receptor 1 shared papers
• D(3) dopamine receptor 1 shared papers
• Filamin-A 1 shared papers

Literature · 10 cited papers

• CXCL17 activates three MAS-related G protein-coupled receptors independently of its conserved C-terminal fragment. Arch. Biochem. Biophys. · 2025
• G Protein-Coupled Receptors Directly Bind Filamin A with High Affinity and Promote Filamin Phosphorylation. Biochemistry · 2015
• Angiotensin-(1-7) Attenuates Angiotensin II-Induced ICAM-1, VCAM-1, and MCP-1 Expression via the MAS Receptor Through Suppression of P38 and NF-kappaB Pathways in HUVECs. Cell. Physiol. Biochem. · 2015
• Angiotensin-(1-7) counterregulates angiotensin II signaling in human endothelial cells. Hypertension · 2007
• Up-regulation of the angiotensin II type 1 receptor by the MAS proto-oncogene is due to constitutive activation of Gq/G11 by MAS. J. Biol. Chem. · 2006
• G-protein-coupled receptor Mas is a physiological antagonist of the angiotensin II type 1 receptor. Circulation · 2005
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
• The DNA sequence and analysis of human chromosome 6. Nature · 2003
• Isolation and characterization of a new cellular oncogene encoding a protein with multiple potential transmembrane domains. Cell · 1986
• The mas oncogene encodes an angiotensin receptor. Nature · 1988