Alpha-1D adrenergic receptor

UniProt P25100 Organism Homo sapiens Gene ADRA1A, ADRA1D

Also known as: ADRA1A, ADRA1D

Function

Alpha-1 adrenergic receptors are G protein-coupled receptors for catecholamines that signal through the G(q) family of G proteins, including G(q) and G(11). Upon activation, they stimulate the phosphatidylinositol-calcium second messenger pathway, leading to calcium release from intracellular stores and activation of protein kinase C. ADRA1D binds the catecholamine ligands norepinephrine and epinephrine.

Classification

Family (Pfam): PF00001 7tm_1
InterPro: ADR_fam, ADRA1D_rcpt, GPCR_Rhodpsn, GPCR_Rhodpsn_7TM
Functional cluster: Nucleic Acid Metabolism & Repair Enzymes

Gene Ontology · 13

Drugs targeting this protein · 39

LABETALOL HYDROCHLORIDE antagonist
PHENYLEPHRINE HYDROCHLORIDE agonist
TETRAHYDROZOLINE HYDROCHLORIDE agonist
MIDODRINE HYDROCHLORIDE agonist
DOXAZOSIN MESYLATE antagonist
HYDROXYAMPHETAMINE HYDROBROMIDE agonist
PHENOXYBENZAMINE HYDROCHLORIDE antagonist
OXYMETAZOLINE HYDROCHLORIDE agonist
DIPIVEFRIN HYDROCHLORIDE agonist
PHENTOLAMINE MESYLATE antagonist
TAMSULOSIN HYDROCHLORIDE antagonist
TRIMIPRAMINE MALEATE antagonist
METHOXAMINE HYDROCHLORIDE agonist
CARVEDILOL PHOSPHATE antagonist
XYLOMETAZOLINE HYDROCHLORIDE agonist
EPINEPHRINE BITARTRATE agonist
SERTINDOLE antagonist
NAFTOPIDIL antagonist
NOREPINEPHRINE BITARTRATE agonist
EPHEDRINE SULFATE agonist
PRAZOSIN HYDROCHLORIDE antagonist
MOXISYLYTE antagonist
TOLAZOLINE HYDROCHLORIDE antagonist
NAPHAZOLINE HYDROCHLORIDE agonist
ALFUZOSIN HYDROCHLORIDE agonist
BUNAZOSIN antagonist
AVIPTADIL antagonist
METARAMINOL BITARTRATE agonist
PHENYLEPHRINE BITARTRATE agonist
DROXIDOPA agonist
BUCINDOLOL HYDROCHLORIDE antagonist
EPHEDRINE HYDROCHLORIDE agonist
ERGOLOID MESYLATES antagonist
ERGOTAMINE TARTRATE agonist
MEPHENTERMINE SULFATE agonist
TERAZOSIN HYDROCHLORIDE antagonist
ISOXSUPRINE HYDROCHLORIDE antagonist
EPINEPHRINE agonist
CARVEDILOL antagonist

Related proteins · sequence + function similarity

Co-cited proteins · studied together in the literature

Alpha-1A adrenergic receptor 3 shared papers
Alpha-1B adrenergic receptor 2 shared papers
Alpha-1D adrenergic receptor 1 shared papers
Proto-oncogene Mas 1 shared papers
D(3) dopamine receptor 1 shared papers
Type-1 angiotensin II receptor 1 shared papers
Filamin-A 1 shared papers

Literature · 7 cited papers

G Protein-Coupled Receptors Directly Bind Filamin A with High Affinity and Promote Filamin Phosphorylation. Biochemistry · 2015
The DNA sequence and comparative analysis of human chromosome 20. Nature · 2001
The alpha 1-adrenergic receptor that mediates smooth muscle contraction in human prostate has the pharmacological properties of the cloned human alpha 1c subtype. Mol. Pharmacol. · 1994
Cloning, expression and characterization of human alpha adrenergic receptors alpha 1a, alpha 1b and alpha 1c. Biochem. Biophys. Res. Commun. · 1994
Cloning and pharmacological characterization of human alpha-1 adrenergic receptors: sequence corrections and direct comparison with other species homologues. J. Pharmacol. Exp. Ther. · 1995
Cloning of the human alpha 1d-adrenergic receptor and inducible expression of three human subtypes in SK-N-MC cells. Mol. Pharmacol. · 1995
Molecular cloning and sequencing of a cDNA encoding a human alpha 1A adrenergic receptor. Biochem. Biophys. Res. Commun. · 1991

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