Alpha-1B adrenergic receptor

Function

Alpha-1 adrenergic receptors are G protein-coupled receptors for catecholamines that signal through the G(q) family of G proteins, including G(q) and G(11). Upon activation, they stimulate the phosphatidylinositol-calcium second messenger pathway, leading to calcium release from intracellular stores and activation of protein kinase C (By similarity). ADRA1B binds the catecholamine ligands norepinephrine and epinephrine. Can also couple to G(14) and G(16) proteins (By similarity). Nuclear ADRA1B forms heterooligomers with ADRA1A to regulate phenylephrine(PE)-stimulated ERK signaling in cardiac myocytes. At the plasma membrane, ADRA1B interacts with CAVIN4/MURC to regulates ERK activation in cardiomyocytes, contributing to the regulation of cardiac hypertrophy.

Classification

Family (Pfam)

PF00001 7tm_1

InterPro

ADR_fam, ADRA1B_rcpt, GPCR_Rhodpsn, GPCR_Rhodpsn_7TM

Functional cluster

G Protein-Coupled Receptors

Gene Ontology · 19

• GO:0005901 caveola
• GO:0005737 cytoplasm
• GO:0031965 nuclear membrane
• GO:0005634 nucleus
• GO:0005886 plasma membrane
• GO:0004937 alpha1-adrenergic receptor activity
• GO:0046982 protein heterodimerization activity
• GO:0071880 adenylate cyclase-activating adrenergic receptor signaling pathway
• GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway
• GO:0007267 cell-cell signaling
• GO:0007186 G protein-coupled receptor signaling pathway
• GO:0035556 intracellular signal transduction
• GO:0150099 neuron-glial cell signaling
• GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway
• GO:0010613 positive regulation of cardiac muscle hypertrophy
• GO:0007204 positive regulation of cytosolic calcium ion concentration
• GO:0043410 positive regulation of MAPK cascade
• GO:0055117 regulation of cardiac muscle contraction
• GO:0019229 regulation of vasoconstriction

Drugs targeting this protein · 38

• LABETALOL HYDROCHLORIDE antagonist
• PHENYLEPHRINE HYDROCHLORIDE agonist
• TETRAHYDROZOLINE HYDROCHLORIDE agonist
• MIDODRINE HYDROCHLORIDE agonist
• DOXAZOSIN MESYLATE antagonist
• HYDROXYAMPHETAMINE HYDROBROMIDE agonist
• PHENOXYBENZAMINE HYDROCHLORIDE antagonist
• OXYMETAZOLINE HYDROCHLORIDE agonist
• DIPIVEFRIN HYDROCHLORIDE agonist
• PHENTOLAMINE MESYLATE antagonist
• TAMSULOSIN HYDROCHLORIDE antagonist
• TRIMIPRAMINE MALEATE antagonist
• METHOXAMINE HYDROCHLORIDE agonist
• CARVEDILOL PHOSPHATE antagonist
• XYLOMETAZOLINE HYDROCHLORIDE agonist
• EPINEPHRINE BITARTRATE agonist
• SERTINDOLE antagonist
• NOREPINEPHRINE BITARTRATE agonist
• EPHEDRINE SULFATE agonist
• PRAZOSIN HYDROCHLORIDE antagonist
• MOXISYLYTE antagonist
• TOLAZOLINE HYDROCHLORIDE antagonist
• NAPHAZOLINE HYDROCHLORIDE agonist
• ALFUZOSIN HYDROCHLORIDE agonist
• BUNAZOSIN antagonist
• AVIPTADIL antagonist
• METARAMINOL BITARTRATE agonist
• PHENYLEPHRINE BITARTRATE agonist
• DROXIDOPA agonist
• BUCINDOLOL HYDROCHLORIDE antagonist
• EPHEDRINE HYDROCHLORIDE agonist
• ERGOLOID MESYLATES antagonist
• ERGOTAMINE TARTRATE agonist
• MEPHENTERMINE SULFATE agonist
• TERAZOSIN HYDROCHLORIDE antagonist
• ISOXSUPRINE HYDROCHLORIDE antagonist
• EPINEPHRINE agonist
• CARVEDILOL antagonist

Related proteins · sequence + function similarity

• Alpha-1B adrenergic receptor 0.99
• Alpha-1B adrenergic receptor 0.99
• Alpha-1B adrenergic receptor 0.98
• Alpha-1B adrenergic receptor 0.95
• Alpha-1D adrenergic receptor 0.92
• Beta-1 adrenergic receptor 0.92
• Alpha-1A adrenergic receptor 0.92
• Alpha-1D adrenergic receptor 0.92
• Alpha-1D adrenergic receptor 0.91
• Alpha-2A adrenergic receptor 0.90
• Alpha-2B adrenergic receptor 0.90
• Alpha-2A adrenergic receptor 0.90

Co-cited proteins · studied together in the literature

• Alpha-1A adrenergic receptor 5 shared papers
• Alpha-1D adrenergic receptor 2 shared papers
• Alpha-1B adrenergic receptor 1 shared papers
• Alpha-1A adrenergic receptor 1 shared papers
• Alpha-1D adrenergic receptor 1 shared papers
• Erbin 1 shared papers
• 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 1 shared papers
• Guanine nucleotide-binding protein G(q) subunit alpha 1 shared papers
• Caveolae-associated protein 4 1 shared papers
• Caveolin-3 1 shared papers
• Caveolae-associated protein 4 1 shared papers
• Caveolin-3 1 shared papers

Literature · 7 cited papers

• MURC/Cavin-4 facilitates recruitment of ERK to caveolae and concentric cardiac hypertrophy induced by alpha1-adrenergic receptors. Proc. Natl. Acad. Sci. U.S.A. · 2014
• Nuclear localization drives alpha1-adrenergic receptor oligomerization and signaling in cardiac myocytes. Cell. Signal. · 2012
• Nuclear alpha1-adrenergic receptors signal activated ERK localization to caveolae in adult cardiac myocytes. Circ. Res. · 2008
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
• The alpha 1-adrenergic receptor that mediates smooth muscle contraction in human prostate has the pharmacological properties of the cloned human alpha 1c subtype. Mol. Pharmacol. · 1994
• Cloning and pharmacological characterization of human alpha-1 adrenergic receptors: sequence corrections and direct comparison with other species homologues. J. Pharmacol. Exp. Ther. · 1995
• Genomic organization and expression of the human alpha 1B-adrenergic receptor. J. Biol. Chem. · 1992