lmmol · Proteins

Alpha-1A adrenergic receptor

UniProt P35348 Organism Homo sapiens Gene ADRA1A, ADRA1C

Also known as: ADRA1A, ADRA1C

Function

Alpha-1 adrenergic receptors are G protein-coupled receptors for catecholamines that signal through the G(q) family of G proteins, including G(q) and G(11). Upon activation, they stimulate the phosphatidylinositol-calcium second messenger pathway, leading to calcium release from intracellular stores and activation of protein kinase C. ADRA1A binds the catecholamine ligands norepinephrine and epinephrine. Can also couple to G(14) protein (By similarity). Nuclear ADRA1A forms heterooligomers with ADRA1B to regulate phenylephrine(PE)-stimulated ERK signaling in cardiac myocytes. At the plasma membrane, ADRA1A interacts with CAVIN4/MURC to regulates ERK activation in cardiomyocytes, contributing to the regulation of cardiac hypertrophy. Additionally, functions as a vasopressor in resistance arteries and plays a role in maintaining normal arterial blood pressure (By similarity).

Classification

Family (Pfam)
PF00001 7tm_1
InterPro
ADR_fam, ADRA1A_rcpt, GPCR_Rhodpsn, GPCR_Rhodpsn_7TM
Functional cluster
G Protein-Coupled Receptors

Experimental structures · PDB · 9

A predicted model is available from AlphaFold.

Gene Ontology · 32

Drugs targeting this protein · 43

Related proteins · sequence + function similarity

Co-cited proteins · studied together in the literature

Literature · 18 cited papers

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