lmmol · Proteins

Alpha-2A adrenergic receptor

UniProt P08913 Organism Homo sapiens Gene ADRA2A, ADRA2R, ADRAR

Also known as: ADRA2A, ADRA2R, ADRAR

Function

Alpha-2 adrenergic receptors are G protein-coupled receptors for catecholamines that activate the G(i/o) protein pathway, thereby promoting adenylyl cyclase inhibition, ERK1/2 stimulation, and voltage-gated calcium channels suppression. Control a variety of physiological processes, such as regulation of blood pressure, lipolysis and insulin release. ADRA2A and ADRA2C mediates the presynaptic feedback inhibition of neurotransmitter release from noradrenergic nerve terminals in sympathetic and central nervous systems. ADRA2A inhibits transmitter release at high stimulation frequencies, whereas ADRA2C modulates neurotransmission at lower levels of nerve activity (By similarity). The rank order of potency for agonists of ADRA2A is oxymetazoline > clonidine > epinephrine > norepinephrine > phenylephrine > dopamine > p-synephrine > p-tyramine > serotonin = p-octopamine. For antagonists, the rank order is yohimbine > phentolamine = mianserine > chlorpromazine = spiperone = prazosin > propanolol > alprenolol = pindolol.

Classification

Family (Pfam)
PF00001 7tm_1
InterPro
ADR_fam, ADRA2A_rcpt, GPCR_Rhodpsn, GPCR_Rhodpsn_7TM
Functional cluster
G Protein-Coupled Receptors

Experimental structures · PDB · 19

A predicted model is available from AlphaFold.

Gene Ontology · 60

Disease associations

Drugs targeting this protein · 39

Related proteins · sequence + function similarity

Co-cited proteins · studied together in the literature

Literature · 14 cited papers

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