Renin

Function

Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney.

Classification

Family (Pfam)

PF07966 A1_Propeptide, PF00026 Asp

InterPro

Aspartic_peptidase_A1, Aspartic_peptidase_AS, Aspartic_peptidase_N, PEPTIDASE_A1, Peptidase_aspartic_dom_sf, Renin-like_dom

Functional cluster

Cytochrome P450 & Heme Enzymes

Experimental structures · PDB · 91

• 1BBS X-ray 2.80A
• 1BIL X-ray 2.40A
• 1BIM X-ray 2.80A
• 1HRN X-ray 1.80A
• 1RNE X-ray 2.40A
• 2BKS X-ray 2.20A
• 2BKT X-ray 2.30A
• 2FS4 X-ray 2.20A
• 2G1N X-ray 2.90A
• 2G1O X-ray 2.70A
• 2G1R X-ray 2.42A
• 2G1S X-ray 2.50A
• … and 79 more

A predicted model is available from AlphaFold.

Gene Ontology · 21

• GO:0045177 apical part of cell
• GO:0005576 extracellular region
• GO:0005615 extracellular space
• GO:0005886 plasma membrane
• GO:0004190 aspartic-type endopeptidase activity
• GO:0005159 insulin-like growth factor receptor binding
• GO:0008233 peptidase activity
• GO:0005102 signaling receptor binding
• GO:0002003 angiotensin maturation
• GO:0071466 cellular response to xenobiotic stimulus
• GO:0072051 juxtaglomerular apparatus development
• GO:0001822 kidney development
• GO:0008584 male gonad development
• GO:0001823 mesonephros development
• GO:0006508 proteolysis
• GO:0008217 regulation of blood pressure
• GO:0043408 regulation of MAPK cascade
• GO:0051591 response to cAMP
• GO:0070305 response to cGMP
• GO:0035902 response to immobilization stress
• GO:0032496 response to lipopolysaccharide

Disease associations

• renal tubular dysgenesis of genetic origin MONDO:0009970
• familial juvenile hyperuricemic nephropathy type 2 MONDO:0013128

Drugs targeting this protein · 4

• ALISKIREN FUMARATE inhibitor
• IMARIKIREN HYDROCHLORIDE inhibitor
• IMARIKIREN inhibitor
• SITOKIREN inhibitor

Related proteins · sequence + function similarity

• Renin 1.00
• Renin 1.00
• Renin 1.00
• Renin 1.00
• Renin 0.97
• Renin-1 0.96
• Renin 0.95
• Renin-2 0.95
• Renin 0.95
• Renin 0.94
• Cathepsin D 0.93
• Renin 0.93

Co-cited proteins · studied together in the literature

• Renin-2 1 shared papers
• Angiotensinogen 3 shared papers
• Angiotensinogen 1 shared papers
• Angiotensinogen 1 shared papers
• Renin receptor 1 shared papers
• Type-1 angiotensin II receptor 1 shared papers
• Angiotensin-converting enzyme 1 shared papers

Literature · 16 cited papers

• A redox switch in angiotensinogen modulates angiotensin release. Nature · 2010
• Dominant renin gene mutations associated with early-onset hyperuricemia, anemia, and chronic kidney failure. Am. J. Hum. Genet. · 2009
• The DNA sequence and biological annotation of human chromosome 1. Nature · 2006
• Mutations in genes in the renin-angiotensin system are associated with autosomal recessive renal tubular dysgenesis. Nat. Genet. · 2005
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
• Pivotal role of the renin/prorenin receptor in angiotensin II production and cellular responses to renin. J. Clin. Invest. · 2002
• Primary structure of the human renin gene. DNA · 1984
• Cloning and sequence analysis of cDNA for human renin precursor. Proc. Natl. Acad. Sci. U.S.A. · 1983
• Molecular cloning and nucleotide sequence of a human renin cDNA fragment. Nucleic Acids Res. · 1983
• New possibilities for intracellular renin and inactive renin now that the structure of the human renin gene has been elucidated. Clin. Sci. · 1986
• Segmental homology between the promoter region of the human renin gene and the mouse ren1 and ren2 promoter regions. Gene · 1986
• Human renin gene of renin-secreting tumor. Gene · 1986
• … and 4 more in the literature graph