Somatostatin receptor type 1

Function

Receptor for somatostatin with higher affinity for somatostatin-14 than -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and Na(+)/H(+) exchanger via pertussis toxin insensitive G proteins.

Classification

Family (Pfam)

PF00001 7tm_1

InterPro

GPCR_Rhodpsn, GPCR_Rhodpsn_7TM, Somatstn_rcpt, Somatstn_rcpt_1

Functional cluster

Membrane Transporters & GPCRs

Experimental structures · PDB · 4

• 8XIO EM 2.65A
• 8XIP EM 3.29A
• 9IK8 EM 2.82A
• 9IK9 EM 3.37A

A predicted model is available from AlphaFold.

Gene Ontology · 12

• GO:0043005 neuron projection
• GO:0005886 plasma membrane
• GO:0042923 neuropeptide binding
• GO:0004994 somatostatin receptor activity
• GO:0071392 cellular response to estradiol stimulus
• GO:0021549 cerebellum development
• GO:0030900 forebrain development
• GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
• GO:0008285 negative regulation of cell population proliferation
• GO:0007218 neuropeptide signaling pathway
• GO:0042594 response to starvation
• GO:0007283 spermatogenesis

Drugs targeting this protein · 4

• OCTREOTIDE ACETATE agonist
• SOMATOSTATIN agonist
• PASIREOTIDE DIASPARTATE agonist
• PASIREOTIDE PAMOATE agonist

Related proteins · sequence + function similarity

• Somatostatin receptor type 1 1.00
• Somatostatin receptor type 1 1.00
• Somatostatin receptor type 1 1.00
• Somatostatin receptor type 4 0.93
• Somatostatin receptor type 5 0.93
• Somatostatin receptor type 4 0.93
• Somatostatin receptor type 5 0.92
• Somatostatin receptor type 5 0.92
• Somatostatin receptor type 4 0.92
• Delta-type opioid receptor 0.92
• Delta-type opioid receptor 0.91
• Delta-type opioid receptor 0.91

Co-cited proteins · studied together in the literature

• Somatostatin receptor type 1 1 shared papers
• Somatostatin receptor type 2 1 shared papers
• Protein arginine N-methyltransferase 5 1 shared papers
• Somatostatin receptor type 2 1 shared papers

Literature · 3 cited papers

• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
• Interaction of the somatostatin receptor subtype 1 with the human homolog of the Shk1 kinase-binding protein from yeast. J. Biol. Chem. · 2000
• Cloning and functional characterization of a family of human and mouse somatostatin receptors expressed in brain, gastrointestinal tract, and kidney. Proc. Natl. Acad. Sci. U.S.A. · 1992