Somatostatin receptor type 2

UniProt P30874 Organism Homo sapiens Gene SSTR2

Also known as: SSTR2

Function

Receptor for somatostatin-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and PLC via pertussis toxin insensitive as well as sensitive G proteins. Inhibits calcium entry by suppressing voltage-dependent calcium channels. Acts as the functionally dominant somatostatin receptor in pancreatic alpha- and beta-cells where it mediates the inhibitory effect of somatostatin-14 on hormone secretion. Inhibits cell growth through enhancement of MAPK1 and MAPK2 phosphorylation and subsequent up-regulation of CDKN1B. Stimulates neuronal migration and axon outgrowth and may participate in neuron development and maturation during brain development. Mediates negative regulation of insulin receptor signaling through PTPN6. Inactivates SSTR3 receptor function following heterodimerization.

Classification

Family (Pfam): PF00001 7tm_1
InterPro: GPCR_Rhodpsn, GPCR_Rhodpsn_7TM, Somatstn_rcpt, Somatstn_rcpt_2
Functional cluster: Membrane Transporters & GPCRs

Experimental structures · PDB · 17

7T10 EM 2.50A
7T11 EM 2.70A
7UL5 EM 3.10A
7WIC EM 2.80A
7WIG EM 2.70A
7WJ5 EM 3.72A
7XAT EM 2.85A
7XAU EM 2.97A
7XAV EM 2.87A
7XMR EM 3.10A
7XN9 X-ray 2.60A
7XNA X-ray 2.65A
… and 5 more

A predicted model is available from AlphaFold.

Gene Ontology · 11

Drugs targeting this protein · 9

Related proteins · sequence + function similarity

Co-cited proteins · studied together in the literature

Somatostatin receptor type 2 2 shared papers
Somatostatin receptor type 5 1 shared papers
Somatostatin receptor type 1 1 shared papers
Somatostatin receptor type 2 1 shared papers
SH3 and multiple ankyrin repeat domains protein 1 1 shared papers
Somatostatin receptor type 1 1 shared papers
SH3 and multiple ankyrin repeat domains protein 1 1 shared papers

Literature · 11 cited papers

SSTR2 is the functionally dominant somatostatin receptor in human pancreatic beta- and alpha-cells. Am. J. Physiol. · 2012
Identification of critical residues involved in ligand binding and G protein signaling in human somatostatin receptor subtype 2. Endocrinology · 2012
The somatostatin 2A receptor is enriched in migrating neurons during rat and human brain development and stimulates migration and axonal outgrowth. PLoS ONE · 2009
Cell growth inhibition and functioning of human somatostatin receptor type 2 are modulated by receptor heterodimerization. Mol. Endocrinol. · 2008
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
Agonist-dependent dissociation of human somatostatin receptor 2 dimers: a role in receptor trafficking. J. Biol. Chem. · 2004
Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat. Genet. · 2004
Genomic structure and transcriptional regulation of the human somatostatin receptor type 2. Mol. Cell. Endocrinol. · 1999
Somatostatin receptor interacting protein defines a novel family of multidomain proteins present in human and rodent brain. J. Biol. Chem. · 1999
Multiple gene transcripts of the somatostatin receptor SSTR2: tissue selective distribution and cAMP regulation. Biochem. Biophys. Res. Commun. · 1993
Cloning and functional characterization of a family of human and mouse somatostatin receptors expressed in brain, gastrointestinal tract, and kidney. Proc. Natl. Acad. Sci. U.S.A. · 1992

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