Somatostatin receptor type 5
Also known as: SSTR5
Function
Receptor for somatostatin 28 and to a lesser extent for somatostatin-14. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. Increases cell growth inhibition activity of SSTR2 following heterodimerization.
Classification
- Family (Pfam)
- PF00001 7tm_1
- InterPro
- GPCR_Rhodpsn, GPCR_Rhodpsn_7TM, Somatstn_rcpt, Somatstn_rcpt_5
- Functional cluster
- G Protein-Coupled Receptors
Experimental structures · PDB · 5
A predicted model is available from AlphaFold.
Gene Ontology · 11
- GO:0043005 neuron projection
- GO:0005886 plasma membrane
- GO:0042923 neuropeptide binding
- GO:0004994 somatostatin receptor activity
- GO:0071385 cellular response to glucocorticoid stimulus
- GO:0007186 G protein-coupled receptor signaling pathway
- GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
- GO:0008285 negative regulation of cell population proliferation
- GO:0007218 neuropeptide signaling pathway
- GO:0032467 positive regulation of cytokinesis
- GO:0050796 regulation of insulin secretion
Drugs targeting this protein · 8
- OCTREOTIDE ACETATE agonist
- LANREOTIDE ACETATE agonist
- SOMATOSTATIN agonist
- VAPREOTIDE agonist
- VELDOREOTIDE agonist
- ONZIGOLIDE agonist
- PASIREOTIDE DIASPARTATE agonist
- PASIREOTIDE PAMOATE agonist
Related proteins · sequence + function similarity
- Somatostatin receptor type 5 0.97
- Somatostatin receptor type 5 0.97
- Somatostatin receptor type 5 0.96
- Somatostatin receptor type 4 0.96
- Somatostatin receptor type 3 0.96
- Somatostatin receptor type 4 0.95
- Somatostatin receptor type 4 0.95
- Somatostatin receptor type 3 0.94
- Somatostatin receptor type 3 0.94
- Neuropeptides B/W receptor type 1 0.92
- Neuropeptides B/W receptor type 1 0.90
- Neuropeptides B/W receptor type 1 0.90
Co-cited proteins · studied together in the literature
- Somatostatin receptor type 4 1 shared papers
- Somatostatin receptor type 5 2 shared papers
- Somatostatin receptor type 2 1 shared papers
- Somatostatin receptor type 5 1 shared papers
- Palmitoyltransferase ZDHHC5 1 shared papers
- Palmitoyltransferase ZDHHC5 1 shared papers
- Palmitoyltransferase ZDHHC5 1 shared papers
Literature · 8 cited papers
- Somatostatin receptor 5 is palmitoylated by the interacting ZDHHC5 palmitoyltransferase. FEBS Lett. · 2011
- Cell growth inhibition and functioning of human somatostatin receptor type 2 are modulated by receptor heterodimerization. Mol. Endocrinol. · 2008
- The sequence and analysis of duplication-rich human chromosome 16. Nature · 2004
- Identification of an upstream pituitary-active promoter of human somatostatin receptor subtype 5. Endocrinology · 2002
- Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16. Hum. Mol. Genet. · 2001
- Cloning, functional expression and pharmacological characterization of a fourth (hSSTR4) and a fifth (hSSTR5) human somatostatin receptor subtype. Biochem. Biophys. Res. Commun. · 1993
- Characterization of cloned human somatostatin receptor SSTR5. Mol. Pharmacol. · 1994
- Molecular cloning, functional characterization, and chromosomal localization of a human somatostatin receptor (somatostatin receptor type 5) with preferential affinity for somatostatin-28. Mol. Pharmacol. · 1994
A document in the lmmol reference corpus — open public data (UniProt, GO, PDB, the literature graph) rendered as a single cross-linked page. Hover any link to preview its target.