Somatostatin receptor type 3

Function

Receptor for somatostatin-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase.

Classification

Family (Pfam)

PF00001 7tm_1

InterPro

GPCR_Rhodpsn, GPCR_Rhodpsn_7TM, Somatstn_rcpt, Somatstn_rcpt_3

Functional cluster

Nucleic Acid Metabolism & Repair Enzymes

Experimental structures · PDB · 3

• 8XIQ EM 2.71A
• 8XIR EM 2.52A
• 8ZBI EM 2.79A

A predicted model is available from AlphaFold.

Gene Ontology · 15

• GO:0097731 9+0 non-motile cilium
• GO:0060170 ciliary membrane
• GO:0005929 cilium
• GO:0043005 neuron projection
• GO:0097730 non-motile cilium
• GO:0005886 plasma membrane
• GO:0004930 G protein-coupled receptor activity
• GO:0042923 neuropeptide binding
• GO:0005102 signaling receptor binding
• GO:0004994 somatostatin receptor activity
• GO:0007267 cell-cell signaling
• GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
• GO:0008628 hormone-mediated apoptotic signaling pathway
• GO:0008285 negative regulation of cell population proliferation
• GO:0007218 neuropeptide signaling pathway

Drugs targeting this protein · 5

• OCTREOTIDE ACETATE agonist
• SOMATOSTATIN agonist
• VAPREOTIDE agonist
• PASIREOTIDE DIASPARTATE agonist
• PASIREOTIDE PAMOATE agonist

Related proteins · sequence + function similarity

• Somatostatin receptor type 3 0.99
• Somatostatin receptor type 3 0.98
• Somatostatin receptor type 5 0.96
• Somatostatin receptor type 5 0.95
• Somatostatin receptor type 5 0.95
• Somatostatin receptor type 5 0.95
• Somatostatin receptor type 4 0.94
• Somatostatin receptor type 4 0.94
• Somatostatin receptor type 4 0.94
• Neuropeptides B/W receptor type 1 0.90
• Galanin receptor type 2 0.89
• Galanin receptor type 2 0.89

Literature · 6 cited papers

• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
• A genome annotation-driven approach to cloning the human ORFeome. Genome Biol. · 2004
• Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat. Genet. · 2004
• The DNA sequence of human chromosome 22. Nature · 1999
• A human somatostatin receptor (SSTR3), located on chromosome 22, displays preferential affinity for somatostatin-14 like peptides. FEBS Lett. · 1993
• Somatostatin receptors, an expanding gene family: cloning and functional characterization of human SSTR3, a protein coupled to adenylyl cyclase. Mol. Endocrinol. · 1992