Somatostatin receptor type 4

Function

Receptor for somatostatin-14. The activity of this receptor is mediated by G proteins which inhibits adenylyl cyclase. It is functionally coupled not only to inhibition of adenylate cyclase, but also to activation of both arachidonate release and mitogen-activated protein (MAP) kinase cascade. Mediates antiproliferative action of somatostatin in tumor cells.

Classification

Family (Pfam)

PF00001 7tm_1

InterPro

GPCR_Rhodpsn, GPCR_Rhodpsn_7TM, Somatstn_rcpt, Somatstn_rcpt_4

Functional cluster

G Protein-Coupled Receptors

Experimental structures · PDB · 2

• 7XMS EM 2.90A
• 7XMT EM 2.80A

A predicted model is available from AlphaFold.

Gene Ontology · 9

• GO:0043005 neuron projection
• GO:0005886 plasma membrane
• GO:0042923 neuropeptide binding
• GO:0004994 somatostatin receptor activity
• GO:0071385 cellular response to glucocorticoid stimulus
• GO:0007186 G protein-coupled receptor signaling pathway
• GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
• GO:0008285 negative regulation of cell population proliferation
• GO:0007218 neuropeptide signaling pathway

Drugs targeting this protein · 3

• OCTREOTIDE ACETATE agonist
• SOMATOSTATIN agonist
• VELDOREOTIDE agonist

Related proteins · sequence + function similarity

• Somatostatin receptor type 4 0.99
• Somatostatin receptor type 4 0.98
• Somatostatin receptor type 5 0.96
• Somatostatin receptor type 5 0.94
• Somatostatin receptor type 3 0.94
• Somatostatin receptor type 3 0.94
• Somatostatin receptor type 5 0.94
• Somatostatin receptor type 5 0.93
• Somatostatin receptor type 3 0.93
• Neuropeptides B/W receptor type 1 0.92
• Somatostatin receptor type 1 0.92
• Somatostatin receptor type 1 0.92

Co-cited proteins · studied together in the literature

• Somatostatin receptor type 5 1 shared papers

Literature · 6 cited papers

• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
• The DNA sequence and comparative analysis of human chromosome 20. Nature · 2001
• Molecular cloning and sequencing of a human somatostatin receptor, hSSTR4. Biochem. Biophys. Res. Commun. · 1993
• Cloning and characterization of a fourth human somatostatin receptor. Proc. Natl. Acad. Sci. U.S.A. · 1993
• Cloning, functional expression and pharmacological characterization of a fourth (hSSTR4) and a fifth (hSSTR5) human somatostatin receptor subtype. Biochem. Biophys. Res. Commun. · 1993
• Cloning and expression of a human somatostatin-14-selective receptor variant (somatostatin receptor 4) located on chromosome 20. Mol. Pharmacol. · 1993