lmmol · Proteins

Nociceptin receptor

UniProt P41146 Organism Homo sapiens Gene OOR, OPRL1, ORL1

Also known as: OOR, OPRL1, ORL1

Function

G protein-coupled opioid receptor that functions as a receptor for the endogenous neuropeptide nociceptin. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling via G proteins mediates inhibition of adenylate cyclase activity and calcium channel activity. Arrestins modulate signaling via G proteins and mediate the activation of alternative signaling pathways that lead to the activation of MAP kinases. Plays a role in modulating nociception and the perception of pain. Plays a role in the regulation of locomotor activity by the neuropeptide nociceptin.

Classification

Family (Pfam)
PF00001 7tm_1
InterPro
GPCR_Rhodpsn, GPCR_Rhodpsn_7TM, Opioid_rcpt, X_opioid_rcpt
Functional cluster
Membrane Transporters & GPCRs

Experimental structures · PDB · 4

A predicted model is available from AlphaFold.

Gene Ontology · 14

Drugs targeting this protein · 3

Related proteins · sequence + function similarity

Literature · 8 cited papers

A document in the lmmol reference corpus — open public data (UniProt, GO, PDB, the literature graph) rendered as a single cross-linked page. Hover any link to preview its target.