lmmol · Proteins

Kappa-type opioid receptor

UniProt P41145 Organism Homo sapiens Gene OPRK, OPRK1

Also known as: OPRK, OPRK1

Function

G protein-coupled opioid receptor that functions as a receptor for endogenous alpha-neoendorphins and dynorphins, but has low affinity for beta-endorphins. Also functions as a receptor for various synthetic opioids and for the psychoactive diterpene salvinorin A. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain. Plays a role in mediating reduced physical activity upon treatment with synthetic opioids. Plays a role in the regulation of salivation in response to synthetic opioids. May play a role in arousal and regulation of autonomic and neuroendocrine functions.

Classification

Family (Pfam)
PF00001 7tm_1
InterPro
GPCR_Rhodpsn, GPCR_Rhodpsn_7TM, Kappa_opi_rcpt, Opioid_rcpt
Functional cluster
Membrane Transporters & GPCRs

Experimental structures · PDB · 28

A predicted model is available from AlphaFold.

Gene Ontology · 46

Drugs targeting this protein · 30

Related proteins · sequence + function similarity

Co-cited proteins · studied together in the literature

Literature · 13 cited papers

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