lmmol · Proteins

Beta-2 adrenergic receptor

UniProt P07550 Organism Homo sapiens Gene ADRB2, ADRB2R, B2AR

Also known as: ADRB2, ADRB2R, B2AR

Function

G protein-coupled receptor for catecholamines that couples to both G(s) and G(i) proteins, activating bifurcated signaling pathways. ADRB2 binds epinephrine (Epi) with an approximately 30-fold greater affinity than norepinephrine (NE). In the heart, Epi- and NE-activated ADRB2 induces rapid and slow cardiomyocyte contraction rate, respectively (By similarity). Both NE and Epi promote coupling to G(s)/PKA pathway to regulate myocyte contraction rate (By similarity). Epi also promotes ADRB2 coupling to G(i) proteins to exert cardioprotective effects especially in the conditions of hypoxia and oxidative stress through the G(i)/PI3K/Akt signaling pathway (By similarity). ADRB2-G(s) signaling delivers proapoptotic signals in cardiomyocytes although G(i)-mediated survival effect appears to predominate (By similarity). ADRB2 also transduces signals independently of PKA to regulate cellular pH by modulating Na(+)/H(+) exchanger SLC9A3 function.

Classification

Family (Pfam)
PF00001 7tm_1
InterPro
ADR_fam, ADRB2_rcpt, GPCR_Rhodpsn, GPCR_Rhodpsn_7TM
Functional cluster
G Protein-Coupled Receptors

Experimental structures · PDB · 139

A predicted model is available from AlphaFold.

Gene Ontology · 41

Disease associations

Drugs targeting this protein · 70

Neighborhood · nearest proteins

ADRB2ADRB2Adrb2ADRB2ARRDC3KIAA0488ADRB1
Nearest neighbours of Beta-2 adrenergic receptor: 3 by sequence/function similarity (left); 3 co-cited in the literature (right).

Related proteins · sequence + function similarity

Co-cited proteins · studied together in the literature

Literature · 37 cited papers

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