Proteasome subunit beta type-9

UniProt P28065 Organism Homo sapiens Gene LMP2, PSMB6i, PSMB9, RING12 EC 3.4.25.1

Also known as: LMP2, PSMB6i, PSMB9, RING12

Function

The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides. Replacement of PSMB6 by PSMB9 increases the capacity of the immunoproteasome to cleave model peptides after hydrophobic and basic residues.

Classification

Family (Pfam): PF00227 Proteasome
InterPro: Ntn_hydrolases_N, Pept_T1A_subB, Proteasome_bsu_CS, Proteasome_sua/b, Proteasome_suB-type
Functional cluster: Tubulins & Mitochondrial Metabolic Enzymes

Experimental structures · PDB · 7

6AVO EM 3.80A
6E5B X-ray 2.77A
7AWE X-ray 2.29A
7B12 X-ray 2.43A
9FRW X-ray 2.85A
9FST X-ray 2.75A
9FSU X-ray 2.75A

A predicted model is available from AlphaFold.

Gene Ontology · 22

Disease associations

proteasome-associated autoinflammatory syndrome 3 MONDO:0054699
proteasome-associated autoinflammatory syndrome 6 MONDO:0968983

Drugs targeting this protein · 7

OPROZOMIB inhibitor
IXAZOMIB inhibitor
BORTEZOMIB inhibitor
IXAZOMIB CITRATE inhibitor
MARIZOMIB inhibitor
CARFILZOMIB inhibitor
BORTEZOMIB D-MANNITOL inhibitor

Related proteins · sequence + function similarity

Co-cited proteins · studied together in the literature

Proteasome subunit beta type-8 15 shared papers
Proteasome subunit beta type-10 7 shared papers
Cytotoxic T-lymphocyte protein 4 1 shared papers
Proteasome maturation protein 2 shared papers
Proteasome subunit beta type-9 2 shared papers
Proteasome subunit beta type-5 3 shared papers
HLA class II histocompatibility antigen, DO beta chain 2 shared papers
Proteasome subunit beta type-8 2 shared papers
Proteasome subunit beta type-4 3 shared papers
Interferon gamma 1 shared papers
Proteasome subunit alpha type-3 3 shared papers
Protein tyrosine phosphatase type IVA 1 1 shared papers

Literature · 27 cited papers

Heterozygous missense variant of the proteasome subunit beta-type 9 causes neonatal-onset autoinflammation and immunodeficiency. Nat. Commun. · 2021
Successful treatment of a novel type I interferonopathy due to a de novo PSMB9 gene mutation with a Janus kinase inhibitor. J. Allergy Clin. Immunol. · 2021
PMID 26829627 J. Clin. Invest. · 2016
Additive loss-of-function proteasome subunit mutations in CANDLE/PRAAS patients promote type I IFN production. J. Clin. Invest. · 2015
Initial characterization of the human central proteome. BMC Syst. Biol. · 2011
Lysine acetylation targets protein complexes and co-regulates major cellular functions. Science · 2009
CD40 induces antigen transporter and immunoproteasome gene expression in carcinomas via the coordinated action of NF-kappaB and of NF-kappaB-mediated de novo synthesis of IRF-1. Mol. Cell. Biol. · 2008
Genome-wide gene expression differences in Crohn's disease and ulcerative colitis from endoscopic pinch biopsies: insights into distinctive pathogenesis. Inflamm. Bowel Dis. · 2007
Heat shock up-regulates lmp2 and lmp7 and enhances presentation of immunoproteasome-dependent epitopes. J. Immunol. · 2006
The catalytic subunit of the proteasome is engaged in the entire process of estrogen receptor-regulated transcription. EMBO J. · 2006
IRF-1 mediates upregulation of LMP7 by IFN-gamma and concerted expression of immunosubunits of the proteasome. FEBS Lett. · 2005
Potential effects of tetrodotoxin exposure to human glial cells postulated using microarray approach. Toxicon · 2004
… and 15 more in the literature graph

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