lmmol · Proteins

Proteasome subunit beta type-8

UniProt P28062 Organism Homo sapiens Gene LMP7, PSMB5i, PSMB8, RING10, Y2 EC 3.4.25.1

Also known as: LMP7, PSMB5i, PSMB8, RING10, Y2

Function

The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides. Replacement of PSMB5 by PSMB8 increases the capacity of the immunoproteasome to cleave model peptides after hydrophobic and basic residues. Involved in the generation of spliced peptides resulting from the ligation of two separate proteasomal cleavage products that are not contiguous in the parental protein. Acts as a major component of interferon gamma-induced sensitivity. Plays a key role in apoptosis via the degradation of the apoptotic inhibitor MCL1. May be involved in the inflammatory response pathway. In cancer cells, substitution of isoform 1 (E2) by isoform 2 (E1) results in immunoproteasome deficiency. Required for the differentiation of preadipocytes into adipocytes.

Classification

Family (Pfam)
PF00227 Proteasome
InterPro
Ntn_hydrolases_N, Pept_T1A_subB, Proteasome_bsu_CS, Proteasome_sua/b, Proteasome_suB-type
Functional cluster
Tubulins & Mitochondrial Metabolic Enzymes

Experimental structures · PDB · 22

A predicted model is available from AlphaFold.

Gene Ontology · 22

Disease associations

Drugs targeting this protein · 7

Related proteins · sequence + function similarity

Co-cited proteins · studied together in the literature

Literature · 36 cited papers

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