Proteasome subunit beta type-10

Function

The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides.

Classification

Family (Pfam)

PF12465 Pr_beta_C, PF00227 Proteasome

InterPro

Ntn_hydrolases_N, Pept_T1A_subB, Proteasome_bsu_C, Proteasome_bsu_CS, Proteasome_sua/b, Proteasome_suB-type

Functional cluster

Tubulins & Mitochondrial Metabolic Enzymes

Experimental structures · PDB · 16

• 6AVO EM 3.80A
• 6E5B X-ray 2.77A
• 6HV3 X-ray 2.70A
• 6HV4 X-ray 3.00A
• 6HV5 X-ray 3.00A
• 6HV7 X-ray 3.40A
• 6HVA X-ray 2.90A
• 6HVR X-ray 2.70A
• 6HVS X-ray 3.10A
• 6HVT X-ray 2.90A
• 6HVU X-ray 2.90A
• 6HVV X-ray 2.70A
• … and 4 more

A predicted model is available from AlphaFold.

Gene Ontology · 24

• GO:0005829 cytosol
• GO:0005634 nucleus
• GO:0000502 proteasome complex
• GO:0005839 proteasome core complex
• GO:0019774 proteasome core complex, beta-subunit complex
• GO:1990111 spermatoproteasome complex
• GO:0004175 endopeptidase activity
• GO:0004298 threonine-type endopeptidase activity
• GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
• GO:0043374 CD8-positive, alpha-beta T cell differentiation
• GO:0160165 CD8-positive, alpha-beta T cell homeostasis
• GO:0006959 humoral immune response
• GO:0002376 immune system process
• GO:0045590 negative regulation of regulatory T cell differentiation
• GO:0032743 positive regulation of interleukin-2 production
• GO:0032760 positive regulation of tumor necrosis factor production
• GO:0032729 positive regulation of type II interferon production
• GO:0010498 proteasomal protein catabolic process
• GO:0010499 proteasomal ubiquitin-independent protein catabolic process
• GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
• GO:0034341 response to type II interferon
• GO:0045063 T-helper 1 cell differentiation
• GO:0072539 T-helper 17 cell differentiation
• GO:0045061 thymic T cell selection

Disease associations

• proteasome-associated autoinflammatory syndrome 5 MONDO:0030924
• immunodeficiency 121 with autoinflammation MONDO:0971001

Drugs targeting this protein · 7

• OPROZOMIB inhibitor
• IXAZOMIB inhibitor
• BORTEZOMIB inhibitor
• IXAZOMIB CITRATE inhibitor
• MARIZOMIB inhibitor
• CARFILZOMIB inhibitor
• BORTEZOMIB D-MANNITOL inhibitor

Related proteins · sequence + function similarity

• Proteasome subunit beta type-10 0.97
• Proteasome subunit beta type-10 0.97
• Proteasome subunit beta type-10 0.97
• Proteasome subunit beta type-7 0.89
• Proteasome subunit beta type-7 0.89
• Probable proteasome subunit beta type-2 0.89
• Proteasome subunit beta type-7 0.88
• Proteasome subunit beta type-7-B 0.88
• Proteasome subunit beta type-7 0.88
• Proteasome subunit beta type-7 0.87
• Proteasome subunit beta type-7-A 0.87
• Probable proteasome subunit beta type-2 0.85

Co-cited proteins · studied together in the literature

• Chymotrypsin-like protease CTRL-1 1 shared papers
• Proteasome subunit beta type-9 7 shared papers
• Proteasome subunit beta type-8 6 shared papers
• Interferon gamma 1 shared papers
• Proteasome subunit beta type-7 2 shared papers
• Protein tyrosine phosphatase type IVA 1 1 shared papers
• Proteasome subunit beta type-10 1 shared papers
• Proteasome subunit beta type-9 1 shared papers
• Proteasome subunit beta type-8 1 shared papers
• Proteasome subunit beta type-3 1 shared papers
• Proteasome subunit beta type-2 1 shared papers
• Proteasome subunit beta type-1 1 shared papers

Literature · 19 cited papers

• Expanding the PRAAS spectrum: De novo mutations of immunoproteasome subunit beta-type 10 in six infants with SCID-Omenn syndrome. Am. J. Hum. Genet. · 2024
• PSMB10, the last immunoproteasome gene missing for PRAAS. J. Allergy Clin. Immunol. · 2020
• An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J. Proteomics · 2014
• Toward a comprehensive characterization of a human cancer cell phosphoproteome. J. Proteome Res. · 2013
• N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. Proc. Natl. Acad. Sci. U.S.A. · 2012
• Initial characterization of the human central proteome. BMC Syst. Biol. · 2011
• CD40 induces antigen transporter and immunoproteasome gene expression in carcinomas via the coordinated action of NF-kappaB and of NF-kappaB-mediated de novo synthesis of IRF-1. Mol. Cell. Biol. · 2008
• Genome-wide gene expression differences in Crohn's disease and ulcerative colitis from endoscopic pinch biopsies: insights into distinctive pathogenesis. Inflamm. Bowel Dis. · 2007
• IRF-1 mediates upregulation of LMP7 by IFN-gamma and concerted expression of immunosubunits of the proteasome. FEBS Lett. · 2005
• Potential effects of tetrodotoxin exposure to human glial cells postulated using microarray approach. Toxicon · 2004
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
• Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat. Genet. · 2004
• … and 7 more in the literature graph