lmmol · Proteins

Vascular endothelial growth factor receptor 1

UniProt P17948 Organism Homo sapiens Gene FLT, FLT1, FRT, VEGFR1 EC 2.7.10.1

Also known as: FLT, FLT1, FRT, VEGFR1

Function

Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFB and PGF, and plays an essential role in the development of embryonic vasculature, the regulation of angiogenesis, cell survival, cell migration, macrophage function, chemotaxis, and cancer cell invasion. Acts as a positive regulator of postnatal retinal hyaloid vessel regression (By similarity). May play an essential role as a negative regulator of embryonic angiogenesis by inhibiting excessive proliferation of endothelial cells. Can promote endothelial cell proliferation, survival and angiogenesis in adulthood. Its function in promoting cell proliferation seems to be cell-type specific. Promotes PGF-mediated proliferation of endothelial cells, proliferation of some types of cancer cells, but does not promote proliferation of normal fibroblasts (in vitro). Has very high affinity for VEGFA and relatively low protein kinase activity; may function as a negative regulator of VEGFA signaling by limiting the amount of free VEGFA and preventing its binding to KDR. Modulates KDR signaling by forming heterodimers with KDR. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate and the activation of protein kinase C. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, leading to activation of phosphatidylinositol kinase and the downstream signaling pathway. Mediates activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Phosphorylates SRC and YES1, and may also phosphorylate CBL. Promotes phosphorylation of AKT1 at 'Ser-473'. Promotes phosphorylation of PTK2/FAK1.

Classification

Family (Pfam)
PF07679 I-set, PF00047 ig, PF13927 Ig_3, PF22971 Ig_VEGFR-1-like_5th, PF07714 PK_Tyr_Ser-Thr, PF21339 VEGFR-1-like_Ig-like, PF17988 VEGFR-2_TMD, PF22854 VEGFR1-3_N_Ig-like
InterPro
Ig-like_dom, Ig-like_dom_sf, Ig-like_fold, Ig_I-set, Ig_sub, Ig_sub2, Ig_V-set, Immunoglobulin_dom, Kinase-like_dom_sf, Prot_kinase_dom, Protein_kinase_ATP_BS, RTK, Ser-Thr/Tyr_kinase_cat_dom, Tyr_kinase_AS, Tyr_kinase_cat_dom, Tyr_kinase_rcpt_3_CS, VEGFR-2_TMD, VEGFR1-3_5th, VEGFR1-3_N_Ig-like, VEGFR1_rcpt
Functional cluster
Immunoglobulin-Domain Cell Adhesion Proteins

Experimental structures · PDB · 12

A predicted model is available from AlphaFold.

Gene Ontology · 30

Drugs targeting this protein · 42

Related proteins · sequence + function similarity

Co-cited proteins · studied together in the literature

Literature · 43 cited papers

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