Regorafenib
SMILES CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)c(F)c2)ccn1
Structure
2D skeletal formula · rendered by chemkit from PubChem 2D coordinates.
Pseudo-3D ball-and-stick · chemkit, from PubChem 3D conformer coordinates.
Protein targets · 18 targets
- Tyrosine-protein kinase ABL1 P00519 · inhibitor · Tyrosine-protein kinase ABL inhibitor
- RAF proto-oncogene serine/threonine-protein kinase P04049 · inhibitor · Serine/threonine-protein kinase RAF inhibitor
- Mast/stem cell growth factor receptor Kit P10721 · inhibitor · Stem cell growth factor receptor inhibitor
- Fibroblast growth factor receptor 1 P11362 · inhibitor · Fibroblast growth factor receptor 1 inhibitor
- Mitogen-activated protein kinase 11 Q15759 · inhibitor · MAP kinase p38 beta inhibitor
- Fibroblast growth factor receptor 2 P21802 · inhibitor · Fibroblast growth factor receptor 2 inhibitor
- Tyrosine-protein kinase FRK P42685 · inhibitor · Tyrosine-protein kinase FRK inhibitor
- Discoidin domain-containing receptor 2 Q16832 · inhibitor · Discoidin domain-containing receptor 2 inhibitor
- Serine/threonine-protein kinase B-raf P15056 · inhibitor · Serine/threonine-protein kinase B-raf inhibitor
- Angiopoietin-1 receptor Q02763 · inhibitor · Tyrosine-protein kinase TIE-2 inhibitor
- Platelet-derived growth factor receptor beta P09619 · inhibitor · Platelet-derived growth factor receptor inhibitor
- Platelet-derived growth factor receptor alpha P16234 · inhibitor · Platelet-derived growth factor receptor inhibitor
- Vascular endothelial growth factor receptor 1 P17948 · inhibitor · Vascular endothelial growth factor receptor inhibitor
- Vascular endothelial growth factor receptor 3 P35916 · inhibitor · Vascular endothelial growth factor receptor inhibitor
- Vascular endothelial growth factor receptor 2 P35968 · inhibitor · Vascular endothelial growth factor receptor inhibitor
- Proto-oncogene tyrosine-protein kinase receptor Ret P07949 · inhibitor · Tyrosine-protein kinase receptor RET inhibitor
- Ephrin type-A receptor 2 P29317 · inhibitor · Ephrin type-A receptor 2 inhibitor
- High affinity nerve growth factor receptor P04629 · inhibitor · Nerve growth factor receptor Trk-A inhibitor
Each resolved target links to its lmmol protein document; action and mechanism are from the bioactivity record.
A document in the lmmol reference corpus — a real compound (PubChem / ChEMBL identity, chemkit-rendered structure) cross-linked to the protein documents it targets. Hover any link to preview its target.