Tyrosine-protein kinase FRK

Function

Non-receptor tyrosine-protein kinase that negatively regulates cell proliferation. Positively regulates PTEN protein stability through phosphorylation of PTEN on 'Tyr-336', which in turn prevents its ubiquitination and degradation, possibly by reducing its binding to NEDD4. May function as a tumor suppressor.

Classification

Family (Pfam)

PF07714 PK_Tyr_Ser-Thr, PF00017 SH2, PF00018 SH3_1

InterPro

Kinase-like_dom_sf, Non-receptor_tyrosine_kinases, Prot_kinase_dom, Protein_kinase_ATP_BS, Ser-Thr/Tyr_kinase_cat_dom, SH2, SH2_dom_sf, SH2_Frk, SH3-like_dom_sf, SH3_domain, Tyr_kinase_AS, Tyr_kinase_cat_dom

Functional cluster

Serine/Threonine Protein Kinases

Gene Ontology · 16

• GO:0035578 azurophil granule lumen
• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0070062 extracellular exosome
• GO:0005576 extracellular region
• GO:0005654 nucleoplasm
• GO:0005634 nucleus
• GO:0005886 plasma membrane
• GO:0035580 specific granule lumen
• GO:0005524 ATP binding
• GO:0004715 non-membrane spanning protein tyrosine kinase activity
• GO:0004713 protein tyrosine kinase activity
• GO:0005102 signaling receptor binding
• GO:0030154 cell differentiation
• GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway
• GO:0000122 negative regulation of transcription by RNA polymerase II

Drugs targeting this protein · 6

• DASATINIB ANHYDROUS inhibitor
• REGORAFENIB inhibitor
• ILORASERTIB inhibitor
• XL-228 inhibitor
• TG100-801 inhibitor
• ENMD-981693 inhibitor

Related proteins · sequence + function similarity

• Tyrosine-protein kinase FRK 0.98
• Tyrosine-protein kinase FRK 0.97
• Tyrosine-protein kinase transforming protein Abl 0.94
• Tyrosine protein-kinase src-2 0.93
• Proto-oncogene tyrosine-protein kinase LCK 0.93
• Tyrosine-protein kinase Lck 0.93
• Proto-oncogene tyrosine-protein kinase LCK 0.93
• Proto-oncogene tyrosine-protein kinase LCK 0.93
• Tyrosine-protein kinase isoform SRK1 0.93
• Proto-oncogene tyrosine-protein kinase LCK 0.93
• Tyrosine-protein kinase Lck 0.92
• Tyrosine-protein kinase Blk 0.92

Co-cited proteins · studied together in the literature

• Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN 1 shared papers

Literature · 12 cited papers

• An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J. Proteomics · 2014
• RAKing in AKT: a tumor suppressor function for the intracellular tyrosine kinase FRK. Cell Cycle · 2009
• Rak functions as a tumor suppressor by regulating PTEN protein stability and function. Cancer Cell · 2009
• Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. Mol. Cell · 2008
• Patterns of somatic mutation in human cancer genomes. Nature · 2007
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
• Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat. Genet. · 2004
• The DNA sequence and analysis of human chromosome 6. Nature · 2003
• Novel protein kinases expressed in human breast cancer. Int. J. Cancer · 1993
• Rak, a novel nuclear tyrosine kinase expressed in epithelial cells. Cell Growth Differ. · 1994
• The nuclear tyrosine kinase Rak associates with the retinoblastoma protein pRb. Cancer Res. · 1995
• Cloning of FRK, a novel human intracellular SRC-like tyrosine kinase-encoding gene. Gene · 1994