Foretinib
SMILES COc1cc2c(Oc3ccc(NC(=O)C4(C(=O)Nc5ccc(F)cc5)CC4)cc3F)ccnc2cc1OCCCN1CCOCC1
Structure
2D skeletal formula · rendered by chemkit from PubChem 2D coordinates.
Pseudo-3D ball-and-stick · chemkit, from PubChem 3D conformer coordinates.
Protein targets · 9 targets
- Receptor-type tyrosine-protein kinase FLT3 P36888 · inhibitor · Tyrosine-protein kinase receptor FLT3 inhibitor
- Mast/stem cell growth factor receptor Kit P10721 · inhibitor · Stem cell growth factor receptor inhibitor
- Hepatocyte growth factor receptor P08581 · inhibitor · Hepatocyte growth factor receptor inhibitor
- Platelet-derived growth factor receptor beta P09619 · inhibitor · Platelet-derived growth factor receptor inhibitor
- Platelet-derived growth factor receptor alpha P16234 · inhibitor · Platelet-derived growth factor receptor inhibitor
- Angiopoietin-1 receptor Q02763 · inhibitor · Tyrosine-protein kinase TIE-2 inhibitor
- Vascular endothelial growth factor receptor 1 P17948 · inhibitor · Vascular endothelial growth factor receptor inhibitor
- Vascular endothelial growth factor receptor 3 P35916 · inhibitor · Vascular endothelial growth factor receptor inhibitor
- Vascular endothelial growth factor receptor 2 P35968 · inhibitor · Vascular endothelial growth factor receptor inhibitor
Each resolved target links to its lmmol protein document; action and mechanism are from the bioactivity record.
A document in the lmmol reference corpus — a real compound (PubChem / ChEMBL identity, chemkit-rendered structure) cross-linked to the protein documents it targets. Hover any link to preview its target.