lmmol · Proteins

Hepatocyte growth factor receptor

UniProt P08581 Organism Homo sapiens Gene MET EC 2.7.10.1

Also known as: MET

Function

Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of these downstream effectors by MET leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. The RAS-ERK activation is associated with the morphogenetic effects while PI3K/AKT coordinates prosurvival effects. During embryonic development, MET signaling plays a role in gastrulation, development and migration of neuronal precursors, angiogenesis and kidney formation. During skeletal muscle development, it is crucial for the migration of muscle progenitor cells and for the proliferation of secondary myoblasts (By similarity). In adults, participates in wound healing as well as organ regeneration and tissue remodeling. Also promotes differentiation and proliferation of hematopoietic cells. May regulate cortical bone osteogenesis (By similarity).

Classification

Family (Pfam)
PF07714 PK_Tyr_Ser-Thr, PF01437 PSI, PF01403 Sema, PF01833 TIG
InterPro
Ig-like_fold, Ig_E-set, IPT_dom, Kinase-like_dom_sf, Plexin, Plexin_repeat, Prot_kinase_dom, Protein_kinase_ATP_BS, PSI, Semap_dom, Semap_dom_sf, Ser-Thr/Tyr_kinase_cat_dom, Tyr_kinase_AS, Tyr_kinase_cat_dom, Tyr_kinase_HGF/MSP_rcpt, WD40/YVTN_repeat-like_dom_sf
Functional cluster
Immunoglobulin-Domain Cell Adhesion Proteins

Experimental structures · PDB · 120

A predicted model is available from AlphaFold.

Gene Ontology · 29

Disease associations

Drugs targeting this protein · 28

Neighborhood · nearest proteins

METMETMETMETinlBMetMST1R
Nearest neighbours of Hepatocyte growth factor receptor: 3 by sequence/function similarity (left); 3 co-cited in the literature (right).

Related proteins · sequence + function similarity

Co-cited proteins · studied together in the literature

Literature · 62 cited papers

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