Crizotinib
SMILES C[C@@H](Oc1cc(-c2cnn(C3CCNCC3)c2)cnc1N)c1c(Cl)ccc(F)c1Cl
Structure
2D skeletal formula · rendered by chemkit from PubChem 2D coordinates.
Pseudo-3D ball-and-stick · chemkit, from PubChem 3D conformer coordinates.
Protein targets · 8 targets
- Hepatocyte growth factor receptor P08581 · inhibitor · Hepatocyte growth factor receptor inhibitor
- ALK tyrosine kinase receptor Q9UM73 · inhibitor · ALK tyrosine kinase receptor inhibitor
- ALK tyrosine kinase receptor Q9UM73 · inhibitor · EML4-ALK inhibitor
- Echinoderm microtubule-associated protein-like 4 Q9HC35 · inhibitor · EML4-ALK inhibitor
- ALK tyrosine kinase receptor Q9UM73 · inhibitor · NPM/ALK (Nucleophosmin/ALK tyrosine kinase receptor) inhibitor
- Nucleophosmin P06748 · inhibitor · NPM/ALK (Nucleophosmin/ALK tyrosine kinase receptor) inhibitor
- Proto-oncogene tyrosine-protein kinase ROS P08922 · inhibitor · Proto-oncogene tyrosine-protein kinase ROS inhibitor
- Macrophage-stimulating protein receptor Q04912 · inhibitor · Macrophage-stimulating protein receptor inhibitor
Each resolved target links to its lmmol protein document; action and mechanism are from the bioactivity record.
A document in the lmmol reference corpus — a real compound (PubChem / ChEMBL identity, chemkit-rendered structure) cross-linked to the protein documents it targets. Hover any link to preview its target.