NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1

Function

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.

Classification

Family (Pfam)

PF08040 NADH_oxidored

InterPro

NDUB1

Functional cluster

Photosystem II Reaction-Center & Antimicrobial Peptides

Experimental structures · PDB · 7

• 5XTC EM 3.70A
• 5XTD EM 3.70A
• 5XTH EM 3.90A
• 5XTI EM 17.40A
• 9CWT EM 3.44A
• 9I4I EM 2.63A
• 9TI4 EM 2.66A

A predicted model is available from AlphaFold.

Gene Ontology · 7

• GO:0005743 mitochondrial inner membrane
• GO:0005739 mitochondrion
• GO:0045271 respiratory chain complex I
• GO:0008137 NADH dehydrogenase (ubiquinone) activity
• GO:0009060 aerobic respiration
• GO:0006120 mitochondrial electron transport, NADH to ubiquinone
• GO:0042776 proton motive force-driven mitochondrial ATP synthesis

Drugs targeting this protein · 2

• METFORMIN HYDROCHLORIDE inhibitor
• ME-344 inhibitor

Related proteins · sequence + function similarity

• NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 1.00
• NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 0.97
• NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 0.92
• NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 0.92
• NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 0.91
• NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 0.90
• Non-classical export protein 1 0.71
• Succinate dehydrogenase subunit 8B, mitochondrial 0.70
• Succinate dehydrogenase subunit 8A, mitochondrial 0.70
• ATP synthase subunit J, mitochondrial 0.69
• Cytochrome c oxidase subunit 7s 0.67
• Cytochrome c oxidase subunit 7e 0.67

Co-cited proteins · studied together in the literature

• NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial 2 shared papers
• Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 1 shared papers
• Glia maturation factor gamma 1 shared papers
• Integral membrane protein 2A 1 shared papers
• Mannose-P-dolichol utilization defect 1 protein 1 shared papers
• Sperm-associated antigen 7 1 shared papers
• Tubulin-specific chaperone A 1 shared papers
• NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 2 shared papers
• NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 1 shared papers
• NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 1 shared papers
• Distal membrane-arm assembly complex protein 1 1 shared papers
• NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 1 shared papers

Literature · 9 cited papers

• Accessory subunits are integral for assembly and function of human mitochondrial complex I. Nature · 2016
• N-terminome analysis of the human mitochondrial proteome. Proteomics · 2015
• N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. Proc. Natl. Acad. Sci. U.S.A. · 2012
• Initial characterization of the human central proteome. BMC Syst. Biol. · 2011
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
• Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat. Genet. · 2004
• The subunit composition of the human NADH dehydrogenase obtained by rapid one-step immunopurification. J. Biol. Chem. · 2003
• The DNA sequence and analysis of human chromosome 14. Nature · 2003
• Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning. Proc. Natl. Acad. Sci. U.S.A. · 1998