NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial
Also known as: NDUFC1
Function
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Classification
- Family (Pfam)
- PF15088 NADH_dh_m_C1
- InterPro
- NDUFC1
- Functional cluster
- Photosystem II Reaction-Center & Antimicrobial Peptides
Experimental structures · PDB · 7
A predicted model is available from AlphaFold.
Gene Ontology · 7
- GO:0005743 mitochondrial inner membrane
- GO:0005739 mitochondrion
- GO:0045271 respiratory chain complex I
- GO:0008137 NADH dehydrogenase (ubiquinone) activity
- GO:0009060 aerobic respiration
- GO:0006120 mitochondrial electron transport, NADH to ubiquinone
- GO:0042776 proton motive force-driven mitochondrial ATP synthesis
Drugs targeting this protein · 2
- METFORMIN HYDROCHLORIDE inhibitor
- ME-344 inhibitor
Related proteins · sequence + function similarity
- NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial 1.00
- NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial 1.00
- NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial 0.98
- NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial 0.98
- NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial 0.97
- NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial 0.93
- Cytochrome c oxidase subunit 8A, mitochondrial 0.83
- Cytochrome c oxidase subunit 8B, mitochondrial 0.83
- Cytochrome c oxidase subunit 8A, mitochondrial 0.82
- Cytochrome c oxidase subunit 8A, mitochondrial 0.82
- Cytochrome c oxidase subunit 8B, mitochondrial 0.82
- Cytochrome c oxidase subunit 8A, mitochondrial 0.82
Co-cited proteins · studied together in the literature
- NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial 2 shared papers
- NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 2 shared papers
- NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 2 shared papers
- NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 2 shared papers
- NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 2 shared papers
- Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 1 shared papers
- Glia maturation factor gamma 1 shared papers
- Integral membrane protein 2A 1 shared papers
- Mannose-P-dolichol utilization defect 1 protein 1 shared papers
- Sperm-associated antigen 7 1 shared papers
- Tubulin-specific chaperone A 1 shared papers
- NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 2 shared papers
Literature · 5 cited papers
- Accessory subunits are integral for assembly and function of human mitochondrial complex I. Nature · 2016
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
- Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat. Genet. · 2004
- Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning. Proc. Natl. Acad. Sci. U.S.A. · 1998
- Identification and primary structure of five human NADH-ubiquinone oxidoreductase subunits. Biochem. Biophys. Res. Commun. · 1997
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