NADH dehydrogenase [ubiquinone] iron-sulfur protein 5
Also known as: NDUFS5
Function
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Classification
- Family (Pfam)
- PF10200 Ndufs5
- InterPro
- NADH_UbQ_OxRdtase_FeS-su5
- Functional cluster
- RuBisCO & Carbon-Fixation Enzymes
Experimental structures · PDB · 7
A predicted model is available from AlphaFold.
Gene Ontology · 9
- GO:0005743 mitochondrial inner membrane
- GO:0005758 mitochondrial intermembrane space
- GO:0005739 mitochondrion
- GO:0045271 respiratory chain complex I
- GO:0008137 NADH dehydrogenase (ubiquinone) activity
- GO:0009060 aerobic respiration
- GO:0006120 mitochondrial electron transport, NADH to ubiquinone
- GO:0032981 mitochondrial respiratory chain complex I assembly
- GO:0042776 proton motive force-driven mitochondrial ATP synthesis
Drugs targeting this protein · 2
- METFORMIN HYDROCHLORIDE inhibitor
- ME-344 inhibitor
Related proteins · sequence + function similarity
- NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 1.00
- NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 1.00
- NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 1.00
- NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 0.99
- NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 0.98
- NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 0.97
- COX assembly mitochondrial protein 2 homolog 0.74
- NADH dehydrogenase [ubiquinone] iron-sulfur protein 5-B 0.72
- Synaptic plasticity regulator PANTS 0.71
- COX assembly mitochondrial protein 2 homolog 0.71
- NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 0.71
- COX assembly mitochondrial protein 2 homolog 0.71
Co-cited proteins · studied together in the literature
- NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 2 shared papers
- NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 2 shared papers
- Iron-sulfur cluster transfer protein NUBPL 1 shared papers
- FAD-dependent oxidoreductase domain-containing protein 1 1 shared papers
- NADH-ubiquinone oxidoreductase chain 3 1 shared papers
- NADH-ubiquinone oxidoreductase chain 5 1 shared papers
- NADH-ubiquinone oxidoreductase chain 4 1 shared papers
- NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 2 shared papers
- NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial 2 shared papers
- Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 1 shared papers
- Glia maturation factor gamma 1 shared papers
- Integral membrane protein 2A 1 shared papers
Literature · 11 cited papers
- Accessory subunits are integral for assembly and function of human mitochondrial complex I. Nature · 2016
- N-terminome analysis of the human mitochondrial proteome. Proteomics · 2015
- An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J. Proteomics · 2014
- N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. Proc. Natl. Acad. Sci. U.S.A. · 2012
- NDUFB7 and NDUFA8 are located at the intermembrane surface of complex I. FEBS Lett. · 2011
- Initial characterization of the human central proteome. BMC Syst. Biol. · 2011
- High-throughput, pooled sequencing identifies mutations in NUBPL and FOXRED1 in human complex I deficiency. Nat. Genet. · 2010
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
- The subunit composition of the human NADH dehydrogenase obtained by rapid one-step immunopurification. J. Biol. Chem. · 2003
- The human NADH:ubiquinone oxidoreductase NDUFS5 (15 kDa) subunit: cDNA cloning, chromosomal localization, tissue distribution and the absence of mutations in isolated complex I-deficient patients. J. Inherit. Metab. Dis. · 1999
- Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning. Proc. Natl. Acad. Sci. U.S.A. · 1998
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