Gamma-aminobutyric acid receptor subunit theta

Function

Theta subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain. GABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit interfaces (By similarity). When activated by GABA, GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient.

Classification

Family (Pfam)

PF02931 Neur_chan_LBD, PF02932 Neur_chan_memb

InterPro

GABAA/Glycine_rcpt, GABAAt_rcpt, Neur_chan_lig-bd, Neur_chan_lig-bd_sf, Neur_channel, Neuro-gated_channel_TM_sf, Neuro_actylchol_rec, Neurotrans-gated_channel_TM, Neurotransmitter_ion_chnl_CS

Functional cluster

Cytochrome P450 & Heme Enzymes

Gene Ontology · 13

• GO:0034707 chloride channel complex
• GO:1902711 GABA-A receptor complex
• GO:0005886 plasma membrane
• GO:0045211 postsynaptic membrane
• GO:0043235 receptor complex
• GO:0004890 GABA-A receptor activity
• GO:0022851 GABA-gated chloride ion channel activity
• GO:0005326 neurotransmitter transmembrane transporter activity
• GO:0004888 transmembrane signaling receptor activity
• GO:1902476 chloride transmembrane transport
• GO:0007214 gamma-aminobutyric acid signaling pathway
• GO:0007165 signal transduction
• GO:0051932 synaptic transmission, GABAergic

Drugs targeting this protein · 66

• GLUTETHIMIDE positive modulator
• DIAZEPAM positive allosteric modulator
• MIDAZOLAM HYDROCHLORIDE positive allosteric modulator
• QUAZEPAM positive allosteric modulator
• SEVOFLURANE positive allosteric modulator
• CHLORDIAZEPOXIDE HYDROCHLORIDE positive allosteric modulator
• DESFLURANE positive allosteric modulator
• TRICLOFOS SODIUM positive modulator
• METHYPRYLON positive allosteric modulator
• TALBUTAL positive allosteric modulator
• SECOBARBITAL SODIUM positive allosteric modulator
• BUTABARBITAL SODIUM positive allosteric modulator
• THIAMYLAL SODIUM positive allosteric modulator
• ISOFLURANE positive allosteric modulator
• ENFLURANE positive modulator
• FLUNITRAZEPAM positive allosteric modulator
• METHOXYFLURANE positive modulator
• ESZOPICLONE positive allosteric modulator
• GANAXOLONE positive allosteric modulator
• CLOTIAZEPAM positive allosteric modulator
• ACAMPROSATE CALCIUM positive modulator
• BREXANOLONE positive allosteric modulator
• CLORAZEPATE DIPOTASSIUM positive allosteric modulator
• ADIPIPLON partial agonist
• PAGOCLONE positive allosteric modulator
• TETRAZEPAM positive allosteric modulator
• ETIFOXINE antagonist
• METHAQUALONE HYDROCHLORIDE positive allosteric modulator
• RESEQUINIL inverse agonist
• TOPIRAMATE positive modulator
• METHAQUALONE positive allosteric modulator
• ESTAZOLAM positive allosteric modulator
• METHOHEXITAL SODIUM positive allosteric modulator
• CLOMETHIAZOLE positive allosteric modulator
• DARIGABAT agonist
• FLURAZEPAM HYDROCHLORIDE positive allosteric modulator
• CENOBAMATE positive allosteric modulator
• FLUMAZENIL allosteric antagonist
• CIPEPOFOL agonist
• ZURANOLONE positive allosteric modulator
• ABP-700 agonist
• PADSEVONIL partial agonist
• LOREDIPLON positive allosteric modulator
• PENTOBARBITAL positive allosteric modulator
• METHARBITAL positive allosteric modulator
• CHLORDIAZEPOXIDE positive allosteric modulator
• CLONAZEPAM positive allosteric modulator
• BUTALBITAL positive allosteric modulator
• REMIMAZOLAM BESYLATE positive allosteric modulator
• PROPOFOL positive allosteric modulator
• OXAZEPAM positive allosteric modulator
• LORAZEPAM positive allosteric modulator
• ETHCHLORVYNOL positive modulator
• TRIAZOLAM positive allosteric modulator
• MIDAZOLAM positive allosteric modulator
• ALPRAZOLAM positive allosteric modulator
• ETOMIDATE positive modulator
• CLOBAZAM positive allosteric modulator
• THIOPENTAL SODIUM positive allosteric modulator
• PRIMIDONE positive allosteric modulator
• HALOTHANE positive allosteric modulator
• TEMAZEPAM positive allosteric modulator
• PRAZEPAM positive allosteric modulator
• HALAZEPAM positive allosteric modulator
• PENTOBARBITAL SODIUM positive allosteric modulator
• MEPROBAMATE agonist

Related proteins · sequence + function similarity

• Gamma-aminobutyric acid receptor subunit theta 0.94
• Acetylcholine receptor subunit beta-type acr-2 0.81
• Acetylcholine receptor subunit beta-like 1 0.80
• Neuronal acetylcholine receptor subunit alpha-2 0.80
• Neuronal acetylcholine receptor subunit alpha-2 0.79
• Gamma-aminobutyric acid receptor subunit pi 0.79
• Acetylcholine receptor subunit alpha 0.79
• Acetylcholine receptor subunit alpha 0.79
• Neuronal acetylcholine receptor subunit alpha-4 0.79
• Gamma-aminobutyric acid receptor subunit pi 0.78
• Acetylcholine receptor subunit alpha 0.78
• Acetylcholine receptor subunit beta-like 2 0.78

Co-cited proteins · studied together in the literature

• Gamma-aminobutyric acid receptor subunit epsilon 1 shared papers
• Gamma-aminobutyric acid receptor subunit theta 1 shared papers
• Gamma-aminobutyric acid receptor subunit gamma-1 1 shared papers
• Gamma-aminobutyric acid receptor subunit beta-1 2 shared papers
• Gamma-aminobutyric acid receptor subunit alpha-2 1 shared papers
• Gamma-aminobutyric acid receptor subunit epsilon 1 shared papers
• Gamma-aminobutyric acid receptor subunit alpha-3 1 shared papers
• Gamma-aminobutyric acid receptor subunit gamma-2 1 shared papers

Literature · 5 cited papers

• Impact of epsilon and theta subunits on pharmacological properties of alpha3beta1 GABAA receptors expressed in Xenopus oocytes. BMC Pharmacol. · 2006
• The DNA sequence of the human X chromosome. Nature · 2005
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
• GABAA receptor epsilon and theta subunits display unusual structural variation between species and are enriched in the rat locus ceruleus. J. Neurosci. · 2000
• Theta, a novel gamma-aminobutyric acid type A receptor subunit. Proc. Natl. Acad. Sci. U.S.A. · 1999