lmmol · Proteins

Gamma-aminobutyric acid receptor subunit epsilon

UniProt P78334 Organism Homo sapiens Gene GABRE

Also known as: GABRE

Function

Epsilon subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain. GABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit interfaces (By similarity). When activated by GABA, GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient (By similarity). GABAARs containing epsilon subunits also permit spontaneous chloride channel activity while preserving the structural information required for GABA-gated openings. GABARs containing epsilon subunit may regulate cardiac function (Probable).

Classification

Family (Pfam)
PF02931 Neur_chan_LBD, PF02932 Neur_chan_memb
InterPro
GABAA/Glycine_rcpt, GABAAe_rcpt, Neur_chan_lig-bd, Neur_chan_lig-bd_sf, Neur_channel, Neuro-gated_channel_TM_sf, Neuro_actylchol_rec, Neurotrans-gated_channel_TM, Neurotransmitter_ion_chnl_CS
Functional cluster
Cytochrome P450 & Heme Enzymes

Gene Ontology · 12

Drugs targeting this protein · 66

Related proteins · sequence + function similarity

Co-cited proteins · studied together in the literature

Literature · 7 cited papers

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