lmmol · Proteins

Gamma-aminobutyric acid receptor subunit alpha-2

UniProt P47869 Organism Homo sapiens Gene GABRA2

Also known as: GABRA2

Function

Alpha subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain. GABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit interfaces (By similarity). When activated by GABA, GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient. Chloride influx into the postsynaptic neuron following GABAAR opening decreases the neuron ability to generate a new action potential, thereby reducing nerve transmission (By similarity). The alpha-2 subunit exhibits synaptogenic activity together with beta-2 and very little to no activity together with beta-3, the gamma-2 subunit being necessary but not sufficient to induce rapid synaptic contacts formation (By similarity).

Classification

Family (Pfam)
PF02931 Neur_chan_LBD, PF02932 Neur_chan_memb
InterPro
GABAA/Glycine_rcpt, GABAAa_rcpt, GABBAa2_rcpt, Gabra-1-6_TM, Gabra-2_ECD, Neur_chan_lig-bd, Neur_chan_lig-bd_sf, Neur_channel, Neuro-gated_channel_TM_sf, Neuro_actylchol_rec, Neurotrans-gated_channel_TM, Neurotransmitter_ion_chnl_CS
Functional cluster
Mixed Regulatory & Membrane Proteins

Experimental structures · PDB · 8

A predicted model is available from AlphaFold.

Gene Ontology · 20

Disease associations

Drugs targeting this protein · 70

Related proteins · sequence + function similarity

Co-cited proteins · studied together in the literature

Literature · 8 cited papers

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