Voltage-gated potassium channel regulatory subunit KCNG1
Also known as: KCNG1
Function
Regulatory alpha-subunit of the voltage-gated potassium (Kv) channel which, when coassembled with KCNB1 or KCNB2, can modulate their expression and their gating kinetics by acting on deactivation upon repolarization and inactivation during maintained depolarization. Potassium channel subunit that does not form functional channels by itself.
Classification
- Family (Pfam)
- PF02214 BTB_2, PF00520 Ion_trans
- InterPro
- BTB/POZ_dom, Ion_trans_dom, K_chnl_volt-dep_Kv, K_chnl_volt-dep_Kv6, SKP1/BTB/POZ_sf, T1-type_BTB, VG_K_chnl, Volt_channel_dom_sf
- Functional cluster
- Nucleic Acid Metabolism & Repair Enzymes
Gene Ontology · 10
- GO:0016020 membrane
- GO:0005886 plasma membrane
- GO:0008076 voltage-gated potassium channel complex
- GO:0015459 potassium channel regulator activity
- GO:0005249 voltage-gated potassium channel activity
- GO:0001508 action potential
- GO:0071805 potassium ion transmembrane transport
- GO:0006813 potassium ion transport
- GO:0051260 protein homooligomerization
- GO:1901379 regulation of potassium ion transmembrane transport
Drugs targeting this protein · 6
- TEDISAMIL blocker
- GUANIDINE HYDROCHLORIDE blocker
- NERISPIRDINE blocker
- DALFAMPRIDINE blocker
- AMIFAMPRIDINE PHOSPHATE blocker
- AMIFAMPRIDINE blocker
Related proteins · sequence + function similarity
- Voltage-gated potassium channel regulatory subunit KCNG1 0.99
- Voltage-gated potassium channel regulatory subunit KCNG1 0.98
- Voltage-gated potassium channel regulatory subunit KCNG4 0.97
- Voltage-gated potassium channel regulatory subunit KCNG4 0.96
- Voltage-gated potassium channel regulatory subunit KCNG2 0.93
- Potassium voltage-gated channel subfamily V member 1 0.90
- Potassium voltage-gated channel subfamily V member 1 0.88
- Potassium voltage-gated channel subfamily V member 1 0.88
- Potassium voltage-gated channel subfamily V member 1 0.88
- Potassium voltage-gated channel subfamily V member 1 0.88
- Potassium voltage-gated channel subfamily V member 1 0.88
- Delayed-rectifier potassium channel regulatory subunit KCNS1 0.87
Co-cited proteins · studied together in the literature
- Voltage-gated potassium channel regulatory subunit KCNF1 1 shared papers
- Voltage-gated potassium channel regulatory subunit KCNG4 1 shared papers
- Voltage-gated potassium channel regulatory subunit KCNG3 1 shared papers
- Potassium voltage-gated channel subfamily B member 1 1 shared papers
- Potassium voltage-gated channel subfamily B member 1 1 shared papers
Literature · 5 cited papers
- Mutation of histidine 105 in the T1 domain of the potassium channel Kv2.1 disrupts heteromerization with Kv6.3 and Kv6.4. J. Biol. Chem. · 2009
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
- Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat. Genet. · 2004
- The DNA sequence and comparative analysis of human chromosome 20. Nature · 2001
- Isolation, characterization, and mapping of two human potassium channels. Biochem. Biophys. Res. Commun. · 1997
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