Potassium voltage-gated channel subfamily V member 1
Also known as: KCNV1
Function
Potassium channel subunit that does not form functional channels by itself. Modulates KCNB1 and KCNB2 channel activity by shifting the threshold for inactivation to more negative values and by slowing the rate of inactivation. Can down-regulate the channel activity of KCNB1, KCNB2, KCNC4 and KCND1, possibly by trapping them in intracellular membranes.
Classification
- Family (Pfam)
- PF02214 BTB_2, PF00520 Ion_trans
- InterPro
- BTB/POZ_dom, Ion_trans_dom, K_chnl_volt-dep_Kv, K_chnl_volt-dep_Kv8.1, SKP1/BTB/POZ_sf, T1-type_BTB, VG_K_chnl, Volt_channel_dom_sf
- Functional cluster
- Eukaryotic Transcription Factors & related
Gene Ontology · 10
- GO:0016020 membrane
- GO:0005886 plasma membrane
- GO:0008076 voltage-gated potassium channel complex
- GO:0008200 ion channel inhibitor activity
- GO:0015459 potassium channel regulator activity
- GO:0005249 voltage-gated potassium channel activity
- GO:0001508 action potential
- GO:0071805 potassium ion transmembrane transport
- GO:0006813 potassium ion transport
- GO:0051260 protein homooligomerization
Drugs targeting this protein · 6
- TEDISAMIL blocker
- GUANIDINE HYDROCHLORIDE blocker
- NERISPIRDINE blocker
- DALFAMPRIDINE blocker
- AMIFAMPRIDINE PHOSPHATE blocker
- AMIFAMPRIDINE blocker
Related proteins · sequence + function similarity
- Potassium voltage-gated channel subfamily V member 1 1.00
- Potassium voltage-gated channel subfamily V member 1 0.99
- Potassium voltage-gated channel subfamily V member 1 0.99
- Potassium voltage-gated channel subfamily V member 1 0.99
- Potassium voltage-gated channel subfamily V member 1 0.99
- Voltage-gated potassium channel regulatory subunit KCNG1 0.91
- Voltage-gated potassium channel regulatory subunit KCNG1 0.90
- Potassium voltage-gated channel subfamily V member 2 0.89
- Voltage-gated potassium channel regulatory subunit KCNG1 0.88
- Voltage-gated potassium channel regulatory subunit KCNG2 0.87
- Voltage-gated potassium channel regulatory subunit KCNF1 0.87
- Voltage-gated potassium channel regulatory subunit KCNF1 0.87
Co-cited proteins · studied together in the literature
- Potassium voltage-gated channel subfamily V member 1 1 shared papers
- Potassium voltage-gated channel subfamily B member 1 2 shared papers
Literature · 4 cited papers
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
- Positional candidate approach for the gene responsible for benign adult familial myoclonic epilepsy. Epilepsia · 2002
- Modes of regulation of shab K+ channel activity by the Kv8.1 subunit. J. Biol. Chem. · 1997
- Kv8.1, a new neuronal potassium channel subunit with specific inhibitory properties towards Shab and Shaw channels. EMBO J. · 1996
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