Potassium voltage-gated channel subfamily V member 2
Also known as: KCNV2
Function
Potassium channel subunit. Modulates channel activity by shifting the threshold and the half-maximal activation to more negative values.
Classification
- Family (Pfam)
- PF02214 BTB_2, PF00520 Ion_trans
- InterPro
- Ion_trans_dom, K_chnl_volt-dep_Kv, K_chnl_volt-dep_Kv5/Kv9, SKP1/BTB/POZ_sf, T1-type_BTB, VG_K_chnl, Volt_channel_dom_sf
- Functional cluster
- Ribosome-Biogenesis GTPases (Obg/Era/Der)
Gene Ontology · 8
- GO:0016020 membrane
- GO:0005886 plasma membrane
- GO:0008076 voltage-gated potassium channel complex
- GO:0015459 potassium channel regulator activity
- GO:0005249 voltage-gated potassium channel activity
- GO:0001508 action potential
- GO:0071805 potassium ion transmembrane transport
- GO:0051260 protein homooligomerization
Disease associations
- cone dystrophy with supernormal rod response MONDO:0012475
Drugs targeting this protein · 6
- TEDISAMIL blocker
- GUANIDINE HYDROCHLORIDE blocker
- NERISPIRDINE blocker
- DALFAMPRIDINE blocker
- AMIFAMPRIDINE PHOSPHATE blocker
- AMIFAMPRIDINE blocker
Related proteins · sequence + function similarity
- Potassium voltage-gated channel subfamily V member 2 0.96
- Potassium voltage-gated channel subfamily V member 1 0.89
- Potassium voltage-gated channel subfamily V member 1 0.89
- Potassium voltage-gated channel subfamily V member 1 0.89
- Potassium voltage-gated channel subfamily V member 1 0.89
- Potassium voltage-gated channel subfamily V member 1 0.89
- Potassium voltage-gated channel subfamily V member 1 0.89
- Potassium voltage-gated channel subfamily V member 1 0.88
- Voltage-gated potassium channel regulatory subunit KCNF1 0.85
- Voltage-gated potassium channel regulatory subunit KCNF1 0.85
- Potassium voltage-gated channel subfamily A member 6 0.85
- Voltage-gated potassium channel regulatory subunit KCNF1 0.85
Co-cited proteins · studied together in the literature
- Potassium voltage-gated channel subfamily B member 1 2 shared papers
- Voltage-gated potassium channel regulatory subunit KCNG4 1 shared papers
- Voltage-gated potassium channel regulatory subunit KCNG3 1 shared papers
Literature · 5 cited papers
- Compound heterozygous KCNV2 variants contribute to cone dystrophy with supernormal rod responses in a Chinese family. Mol. Genet. Genomic Med. · 2021
- Mutations in the gene KCNV2 encoding a voltage-gated potassium channel subunit cause 'cone dystrophy with supernormal rod electroretinogram' in humans. Am. J. Hum. Genet. · 2006
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
- DNA sequence and analysis of human chromosome 9. Nature · 2004
- Obligatory heterotetramerization of three previously uncharacterized Kv channel alpha-subunits identified in the human genome. Proc. Natl. Acad. Sci. U.S.A. · 2002
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