Voltage-gated potassium channel regulatory subunit KCNG4
Also known as: KCNG3, KCNG4
Function
Regulatory subunit of the voltage-gated potassium (Kv) channel which, when coassembled with KCNB1, modulates the kinetics parameters of the heterotetrameric channel namely the time course of activation, deactivation and inactivation and on the voltage-dependence of activation. Potassium channel subunit that does not form functional channels by itself (Probable). Reduces the deactivation rate. Modulates the threshold for activation by shifting by approximately 20 mV in hyperpolarizing direction. Markedly changes the inactivation by shifting the voltage dependence of inactivation by approximately 40 mV in hyperpolarizing direction. Acceleratee activation and enhances the time course of activation.
Classification
- Family (Pfam)
- PF02214 BTB_2, PF00520 Ion_trans
- InterPro
- Ion_trans_dom, K_chnl_volt-dep_Kv, K_chnl_volt-dep_Kv5/Kv9, SKP1/BTB/POZ_sf, T1-type_BTB, VG_K_chnl, Volt_channel_dom_sf
- Functional cluster
- Secreted Growth Factors & Cytokines
Gene Ontology · 11
- GO:0016020 membrane
- GO:0005886 plasma membrane
- GO:0008076 voltage-gated potassium channel complex
- GO:0015459 potassium channel regulator activity
- GO:0044325 transmembrane transporter binding
- GO:0005249 voltage-gated potassium channel activity
- GO:0001508 action potential
- GO:0071805 potassium ion transmembrane transport
- GO:0051260 protein homooligomerization
- GO:1901379 regulation of potassium ion transmembrane transport
- GO:0043266 regulation of potassium ion transport
Drugs targeting this protein · 6
- TEDISAMIL blocker
- GUANIDINE HYDROCHLORIDE blocker
- NERISPIRDINE blocker
- DALFAMPRIDINE blocker
- AMIFAMPRIDINE PHOSPHATE blocker
- AMIFAMPRIDINE blocker
Related proteins · sequence + function similarity
- Voltage-gated potassium channel regulatory subunit KCNG4 0.99
- Voltage-gated potassium channel regulatory subunit KCNG1 0.96
- Voltage-gated potassium channel regulatory subunit KCNG1 0.96
- Voltage-gated potassium channel regulatory subunit KCNG1 0.96
- Voltage-gated potassium channel regulatory subunit KCNG2 0.92
- Potassium voltage-gated channel subfamily V member 1 0.87
- Potassium voltage-gated channel subfamily V member 1 0.86
- Potassium voltage-gated channel subfamily V member 1 0.86
- Potassium voltage-gated channel subfamily V member 1 0.86
- Potassium voltage-gated channel subfamily V member 1 0.86
- Potassium voltage-gated channel subfamily V member 1 0.86
- Potassium voltage-gated channel subfamily V member 1 0.84
Co-cited proteins · studied together in the literature
- Voltage-gated potassium channel regulatory subunit KCNG3 2 shared papers
- Potassium voltage-gated channel subfamily V member 2 1 shared papers
- Voltage-gated potassium channel regulatory subunit KCNG1 1 shared papers
- Potassium voltage-gated channel subfamily B member 1 2 shared papers
- Potassium voltage-gated channel subfamily B member 1 1 shared papers
Literature · 3 cited papers
- Mutation of histidine 105 in the T1 domain of the potassium channel Kv2.1 disrupts heteromerization with Kv6.3 and Kv6.4. J. Biol. Chem. · 2009
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
- Obligatory heterotetramerization of three previously uncharacterized Kv channel alpha-subunits identified in the human genome. Proc. Natl. Acad. Sci. U.S.A. · 2002
A document in the lmmol reference corpus — open public data (UniProt, GO, PDB, the literature graph) rendered as a single cross-linked page. Hover any link to preview its target.