Voltage-gated potassium channel regulatory subunit KCNG3

UniProt Q8TAE7 Organism Homo sapiens Gene KCNG3

Also known as: KCNG3

Function

Regulatory subunit of the voltage-gated potassium (Kv) channel which, when coassembled with KCNB1, modulates the kinetics parameters of the heterotetrameric channel namely the inactivation and deactivation rate. Potassium channel subunit that does not form functional channels by itself. Reduces the deactivation rate. Moderately accelerates activation.

Classification

Family (Pfam): PF02214 BTB_2, PF00520 Ion_trans
InterPro: BTB/POZ_dom, Ion_trans_dom, K_chnl_volt-dep_Kv, K_chnl_volt-dep_Kv5/Kv9, SKP1/BTB/POZ_sf, T1-type_BTB, VG_K_chnl, Volt_channel_dom_sf
Functional cluster: Nucleic Acid Metabolism & Repair Enzymes

Gene Ontology · 11

Drugs targeting this protein · 6

Related proteins · sequence + function similarity

Co-cited proteins · studied together in the literature

Voltage-gated potassium channel regulatory subunit KCNG3 1 shared papers
Voltage-gated potassium channel regulatory subunit KCNG4 2 shared papers
Potassium voltage-gated channel subfamily B member 1 3 shared papers
Potassium voltage-gated channel subfamily V member 2 1 shared papers
Voltage-gated potassium channel regulatory subunit KCNG1 1 shared papers
Potassium voltage-gated channel subfamily B member 1 1 shared papers

Literature · 5 cited papers

Mutation of histidine 105 in the T1 domain of the potassium channel Kv2.1 disrupts heteromerization with Kv6.3 and Kv6.4. J. Biol. Chem. · 2009
Generation and annotation of the DNA sequences of human chromosomes 2 and 4. Nature · 2005
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
Obligatory heterotetramerization of three previously uncharacterized Kv channel alpha-subunits identified in the human genome. Proc. Natl. Acad. Sci. U.S.A. · 2002
Molecular cloning and characterization of Kv6.3, a novel modulatory subunit for voltage-gated K(+) channel Kv2.1. FEBS Lett. · 2002

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