Delayed-rectifier potassium channel regulatory subunit KCNS2

UniProt Q9ULS6 Organism Homo sapiens Gene KCNS2, KIAA1144

Also known as: KCNS2, KIAA1144

Function

Potassium channel regulatory subunit that modulate the delayed rectifier voltage-gated potassium channel activity of KCNB1 and KCNB2 by altering their kinetics, expression levels, and shifting the half-inactivation potential to more polarized values. While it does not form functional channels on its own, it can form functional heterotetrameric channels with KCNB1 and KCNB2. Each regulatory subunit has unique regulatory properties that can lead to extensive inhibition, significant changes in kinetics, and/or substantial shifts in the voltage dependencies of the inactivation process.

Classification

Family (Pfam): PF02214 BTB_2, PF00520 Ion_trans
InterPro: BTB/POZ_dom, Ion_trans_dom, K_chnl_volt-dep_Kv, K_chnl_volt-dep_Kv5/Kv9, SKP1/BTB/POZ_sf, T1-type_BTB, VG_K_chnl, Volt_channel_dom_sf
Functional cluster: Cytochrome P450 & Heme Enzymes

Gene Ontology · 11

Drugs targeting this protein · 6

Related proteins · sequence + function similarity

Literature · 3 cited papers

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat. Genet. · 2004
Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain. DNA Res. · 1999

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